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- Bookvolume editors, Martin Wabitsch, Carsten Posovszky.Contents:
Gastrointestinal hormones induced the birth of endocrinology / Wabitsch, M.
The changing concept of gut endocrinology / Rehfeld, J.F.
Development and anatomy of the enteroendocrine system in humans / Posovszky, C.
Incretins and their endocrine and metabolic functions / Seufert, J.
Role of incretin hormones in bowel diseases / Zietek, T., Waldschmitt, N., Rath, E.
Ghrelin and growth / Perchard, R., Clayton, P.E.
Development of sweet taste perception : implications for artificial sweetener use / Sylvetsky, A.C., Conway, E.M., Malhotra, S., Rother, K.I.
Just a gut feeling : central nervous effects of peripheral gastrointestinal hormones / RoTh, C.L., Doyle, R.P.
Gastrointestinal endocrinology in bariatric surgery / Wabitsch, M.
Enteroendocrine cells : metabolic relays between microbes and their host / Plovier, H., Cani, P.D.
Treatment of diabetes and obesity by rationally designed peptide agonists functioning at multiple metabolic receptors / Khajavi, N., Biebermann, H., Tschöp, M., DiMarchi, R.Digital Access Karger 2017 - ArticleInoue S, Campfield LA, Bray GA.Am J Physiol. 1977 Sep;233(3):R162-8.The heterogeneous nature of the experimental obesities induced by ventromedial hypothalamic (VMH) lesion and high fat diet (HFD) have been demonstrated by comparing VMH-lesioned and sham-operated rats fed a HFD or low fat diet (LFD). VMH rats had increased fat mass serum insulin and serum triglycerides but lower serum glucagon and smaller salivary glands than sham-operated animals. The body weight of HFD obese rats was intermediate between VMH and sham-operated animals on the LDF. Liver and fat pad weights showed effects of lesions and diet. Diet did not affect plasma glucagon or insulin. Pair-feeding VMH rats with sham-operated rats prevented weight gain but did not prevent the increase in insulin and fall in glucagon. Studies of insulin secretion from isolated perifused islets showed that basal and both phases of stimulated secretion were significantly increased in VMH groups. The changes in plasma insulin, plasma glucagon, and salivary gland weight in VMH groups are interpreted as showing decreased activity of the sympathetic nervous system following VMH lesions.