BookAyse Basak Engin, Atilla Engin, editors.
Summary: "Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. "Obesity and Lipotoxicity" is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. "Lipotoxicity and Obesity" will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field"--Publisher's description.
Contents:
The definition and prevalence of obesity and metabolic syndrome / Atilla Engin
Circadian rhythms in diet-induced obesity / Atilla Engin
Eat and death: chronic over-eating / Atilla Engin
Obesity, persistent organic pollutants and related health problems / Loukia Vassilopoulou, Christos Psycharakis, Demetrios Petrakis, John Tsiaoussis [and others]
Human protein kinases and obesity / Atilla Engin
Fat cell and fatty acid turnover in obesity / Atilla Engin
Adipose tissue function and expandability as determinants of lipotoxicity and the metabolic syndrome / Stefania Carobbio, Vanessa Pellegrinelli, Antonio Vidal-Puig
What is lipotoxicity? / Ayse Basak Engin
The pathogenesis of obesity-associated adipose tissue inflammation / Atilla Engin
Microbiota and lipotoxicity / Evren Doruk Engin
Endoplasmic reticulum stress and obesity / Erkan Yilmaz
Insulin resistance, obesity and lipotoxicity / Dilek Yazıcı, Havva Sezer
Adipose tissue hypoxia in obesity and its impact on preadipocytes and macrophages: hypoxia hypothesis / Atilla Engin
Adipocyte-macrophage cross-talk in obesity / Ayse Basak Engin
Endothelial dysfunction in obesity / Atilla Engin
Diet-induced obesity and the mechanism of leptin resistance / Atilla Engin
Influence of antioxidants on leptin metabolism and its role in the pathogenesis of obesity / Harald Mangge, Christian Ciardi, Kathrin Becker, Barbara Strasser, Dietmar Fuchs [and others]
Adiponectin-resistance in obesity / Atilla Engin
Non-alcoholic fatty liver disease / Atilla Engin
Lipotoxicity-related hematological disorders in obesity / Ibrahim Celalettin Haznedaroglu, Umit Yavuz Malkan
MicroRNA and adipogenesis / Ayse Basak Engin
The interactions between kynurenine, folate, methionine and pteridine pathways in obesity / Ayse Basak Engin, Atilla Engin
Eligibility and success criteria for bariatric/metabolic surgery / Manuel F. Landecho, Víctor Valentí, Rafael Moncada, Gema Frühbeck
Does bariatric surgery improve obesity associated comorbid conditions / Atilla Engin
Obesity-associated breast cancer: analysis of risk factors / Atilla Engin
Lipotoxicity in obesity: benefit of olive oil / Saad Elias, Sbeit Wisam, Arraf Luai, Barhoum Massad, Assy.