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  • Book
    Walter K.H. Krause, Rajesh K. Naz, editors.
    Summary: This book offers comprehensive coverage of both basic and clinical aspects of immune reactions responsible for infertility. It has four sections focusing on Sperm antigens, Antisperm antibodies (ASAs), Clinical impact of ASAs, and Immune contraception, and include contributions from leading experts in these fields. This new edition of the book offers a comprehensive update that reflects the very significant advances in reproductive immunology that have been achieved over the past five years, especially related to the sperm proteome, sperm-egg binding/fusion proteins, gene knockout studies, and immunocontraception. Reproductive immunology continues to be a fast-growing discipline in which new knowledge is emerging almost every day. Immune Infertility is a model source of vital and reliable information on the latest scientific developments in the field. It will be of value for clinicians, scientists, students, residents, and fellows working in reproductive biology, obstetrics and gynecology, and urology.

    Contents:
    Part I Sperm antigens: Proteomics of spermatozoa
    Sperm surface proteome
    Methods of Analysis of Sperm Antigens Related to Fertility
    Sperm functions influenced by immune reactions
    Part II Antisperm antibodies (ASA): The immune privilege of the testis
    Immune chemistry of ASA
    Sperm-specific T cells
    Site and risk factors of ASA production
    Biologic substrates containing ASA
    ASA in the female
    Sperm immobilising ASA
    Part III The clinical impact of sperm antibodies: Autoimmune infertility
    Tests for sperm antibodies
    Impact on fertility outcome
    Sperm antibodies and assisted reproduction
    Treatment of immune infertility
    Part IV Immune contraception: Immunization with Sperm Antigens to Induce Contraception
    Immune contraception in wildlife animals
    Experience from Clinical Trials with Fertility Control Vaccines.
    Digital Access Springer 2017
  • Article
    Tashkin DP, Levisman JA, Abbasi AS, Shapiro BJ, Ellis NM.
    Chest. 1977 Jul;72(1):20-6.
    The short-term effects of smoking one to three marihuana cigarettes (900 mg of marihuana per cigarette; 2.2% delta9-tetrahydrocannabinol) on left ventricular performance were evaluated in 21 experienced users of cannabis at different times during a 94-day in-hospital study of the biologic effect of daily heavy smoking of marihuana. In six subjects, cardiac output was determined using the indocyanine-green dye-dilution technique; and in two of these individuals and 15 additional subjects, cardiac output, ejection fraction, preejection period (PEP), left ventricular ejection time (LVET), and the velocity of circumferential fiber shortening (Vcf) were determined using echocardiograms, phonocardiograms, and carotid pulse recordings. Following the smoking of one to three marihuana cigarettes, the heart rate rose 16 to 53 percent, cardiac output rose 4 to 9 percent, stroke volume did not change or fell slightly, and ejection fraction, PEP/LVET, and did not change, except for a slight increase in Vcf (15%) after three marihuana cigarettes, which could be accounted for by the associated increase in heart rate (53%). These findings suggest that in long-term heavy users of cannabis, marihuana has no significant effect on myocardial contractility independent of its effect on heart rate.
    Digital Access Access Options