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  The Right therapy for neurological disorders : from randomized trials to clinical practice

  volume editors, E. Beghi, G. Logroscino.

  Contents:
  The basic structure of a randomized clinical trial / Beghi, E
  Peculiarities of neurological disorders and study designs / Beghi, E., Pupillo, E. Giussani, G.
  Current issues in randomized clinical trials of neurodegenerative disorders at enrollment and reporting : diagnosis, recruitment, representativeness of patients, ethnicity, and quality of reporting / Logroscino, G., Capozzo, R., Tortelli, R., Marin, B.
  How to distinguish between statistically significant results and clinically relevant results / Bennett, D.A.
  Modeling and prediction in neurological disorders : the biostatistical perspective / Copetti, M. Fontana, A., Pellegrini, F.
  Composite scores and other outcome measures in stroke trial / Pistoia, F., Sacco, S., Ornello, R., Degan, D., Tiseo, C., Carolei, A.
  Age, comorbidity, frailty in observational and analytic studies of neurological diseases / Novy, J., Sander, J.W.
  Disease course, outcome measures, and prognostic predictors in epilepsy : opportunities for improving outcome of drug trials / Schmidt, D.
  Assessing functional decline in neurological diseases clinical trials : duration of follow-up : the case of multiple sclerosis / Martinelli Boneschi, F., Comi, G.
  Biomarkers in randomized clinical trials : magnetic resonance imaging / Whitwell, J.L.
  Biomarkers in randomized clinical trials : positron emission tomography and nuclear medicine techniques / Singhal, T., Stern, E
  Cerebrospinal fluid biomarkers for target engagement and efficacy in clinical trials for Alzheimer's and Parkinson's diseases / Parnetti, L., Eusebi, P., Lleó, A
  Pharmacogenetics in neurodegenerative diseases: implications for clinical trials / Tortelli, R., Seripa, D., Panza, F., Solfrizzi, V., Logroscino, G.
  Randomized trials in developing countries : different priorities and study design? / Marin, B., Agbota, G.C., Preux, P.-M., Boumédiène, F.
  The right therapy for neurological disorders : from randomized trials to clinical practice : patients versus investigator expectations and needs / Bruijn, L.I., Kolb, S.
  General overview, conclusions, and future directions / Beghi, E., Logroscino, G.

  Digital Access Karger 2016
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• Article

  Action d'effecteurs pharmacologiques sur les variations de l'hématocrite et de l'activité lactate déshydrogénasique au cours du choc ischémique expérimental [Action of pharmacological effectors on hematocrit and lactate dehydrogenase activity changes in experimental ischemic shock].

  Jonadet M, Bastide P.

  Pathol Biol (Paris). 1977 Mar;25(3):147-51.

  The experimental ischemic shock induced by removing tourniquets in rats, were studied. Durin 164 hours, the variations of the values of hematocrit and of muscle and plasma dehydrogenase lactate activity were followed up; the modifications of these variations after pharmacological high doses of dexamethasone phosphate, hydrocortisone hemisuccinate and aprotinine administered intravenously, were evaluated. The best action was noted after dexamethasone phosphate treatment.

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  PubMed