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  • Book
    M. Brock Fenton, Alan D Grinnell, Arthur N. Popper, Richard R. Fay, editors.
    Contents:
    Preface
    A History of the Study of Echolocation
    Phylogeny, Genes, and Hearing
    Implications for the Evolution of Echolocation in Bats
    Ultrasound Production, Emission, and Reception
    To Scream or to Listen? Prey Detection and Discrimination in Animal-Eating Bats
    Roles of Acoustic Social Communication in the Lives of Bats
    Guild Structure and Niche Differentiation in Echolocating Bats
    Neural Coding of Signal Duration and Complex Acoustic Objects
    The Neural Processing of Frequency Modulations in the Auditory System of Bats
    Behavioral and Physiological Bases for Doppler Shift Compensation by Echolocating Bats
    Perceiving the World Through Echolocation and Vision
    Perspectives and Challenges for Future Research in Bat Hearing
    Index.
    Digital Access Springer 2016
  • Article
    Frankel RJ, Reid IA, Ganong WF.
    J Pharmacol Exp Ther. 1977 May;201(2):400-5.
    The mechanism by which alpha-methyldopa lowers arterial pressure and suppresses renin secretion was investigated in pentobarbital-anesthetized dogs in which changes in renal perfusion pressure were prevented by adjusting a suprarenal aortic clamp. After intravenous alpha-methyldopa (100 mg/kg) mean arterial pressure (MAP) decreased form 127+/-3 to a mean minimum of 107+/-4 mm Hg (P less than .01) and plasma renin activity (PRA) decreased from 20.6+/-4.8 to 10.9+/-1.7 ng/ml/3 hr (P less than .05). Blockade of peripheral dopa decarboxylase with intravenous carbidopa (20 mg/kg) significantly attenuated the hypotensive action of intravenous alpha-methyldopa but MAP still decreased from 145+/-6 to 130+/-5 mm Hg(P less than .001). Intravenous carbidopa completely abolished the fall in PRA produced by intravenous alpha-methyldopa (16.8+/-2.8 to 16.9+/-2.1 ng/ml/3 hr.) Intraventricular carbidopa (3 microng/kg/min) did not block the hypotensive (135+/-8 to 113+/-7 mm Hg, P less than .01) or renin-lowering effect (24.3+/-5 to 13.4+/-3.2 ng/ml/3 hr, P less than .01) of intravenous alpha-methyldopa (0.5 mg/kg decreased MAP from 118 +/- 5 to 104 +/- 5 mm Hg (P less than 0.001) but had no effect on PRA (23.4+/-6 TO 19.4+/-7 NG/ML/3 hr.) Intraventricular alpha-methylnorepinephrine (2 microng/kg) also decreased MAP from 127+/-5 to 112+/-3mm Hg (P less than .006) but again failed to significantly alter PRA (36.1+/-11.8 to 37.2+/-15 ng/ml/3 hr). These results indicate that there is both a central and peripheral component to the antihypertensive effect of alpha-methyldopa in the dog and that the suppression of renin secretion results from a peripheral action of the drug.
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