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  • Book
    Esteban Domingo, Peter Schuster, editors.
    Contents:
    What is a quasispecies?- Historical origins and current scope
    The nucleation of semantic information in prebiotic matter
    Evolution of RNA-based networks
    Quasispecies on fitness landscapes
    Mathematical models of quasispecies theory and exact results for the dynamics
    Theoretical Models of Generalized Quasispecies
    Theories of lethal mutagenesis: from error catastrophe to lethal defection
    Estimating fitness of viral quasispecies from next-generation sequencing data
    Getting to know viral evolutionary strategies: Towards the next generation of quasispecies models
    Cooperative Interaction within RNA Virus Mutant Spectra
    Arenavirus Quasispecies And Their Biological Implications
    Models of viral population dynamics
    Fidelity variants and RNA quasispecies
    Antiviral strategies based on lethal mutagenesis and error threshold.
    Digital Access Springer 2016
    Access via Current topics in microbiology and immunology ; 2016; 392
    Location
    Version
    Call Number
    Items
    Current topics in microbiology and immunology ; 2016; 392
    2016
  • Article
    Swaney LM, Liu YP, To CM, To CC, Ippen-Ihler K, Brinton CC.
    J Bacteriol. 1977 Apr;130(1):495-505.
    Type 1 pili of Escherichia coli are the prototype of the somatic class of pili found on many strains of bacteria. As a first step in the genetic analysis of type 1 piliation, an extensive series of nonpiliated derivatives of E. coli K-12 strain AW405, was characterized to produce attached or free pili when examined in the antiserum or appeared to produce attached or free pili when examined in the electron microscope. The derivatives fell into two classes; phase variants and mutants. Phase variants that formed colonies of two distinctive types, one associated with a predominantly piliated (P+), and the other associated with a nonpiliated (P-) phase, were obtained. Each phase could give rise to the other at a relatively high rate, which was greater in the P- to P+ direction during culture in unshaken liquid medium. In addition, 77 Pil- mutants were selected on the basis of a subtle difference in colonial morphology. The mutants reverted, if at all, at a much lower rate than that of the P- to P+ change. The stability of Pil- derivatives grown in unshaken liquid medium was used as a criterion for distinguishing between phase variants and mutants, Phase variation also effected colonial morphology and chemotactic swarming. These properties did not directly depend upon piliation since Pil- mutants were only slightly altered in colonial form and unaltered in chemotactic swarming. Piliation of Pil+ bacteria was quantitatively affected by growth conditions.
    Digital Access Access Options