BookAmy K. Reeve, Eve M. Simcox, Michael R. Duchen, Doug M. Turnbull, editors.
Contents:
Part I. Mitochondria and Neurodegenerative Disease
An Introduction to Mitochondria, Their Structure and Functions
Part II. Mitochondrial Dysfunction: Causes and Effects?
Neurodegeneration in Mitochondrial Disorders
The Ageing Brain, Mitochondria and Neurodegeneration
Mitochondrial Genes and Neurodegenerative Disease
Mitochondrial Signalling and Neurodegeneration
Part III. Functional Consequences of Mitochondrial Dysfunction
Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson's Disease
Mitochondrial Dynamics and Neurodegeneration
Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation
Mitochondria, the Synapse, and Neurodegeneration
Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration
Mitochondrial Degradation, Autophagy and Neurodegenerative Disease
The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria
Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease
Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration?
Mitochondrial Function and Dynamics Imaged In Vivo
Part V. The Future
Development of Treatments and Therapies to Target Mitochondrial Dysfunction
Summary and Conclusions.