Search
Filter Results
- Resource Type
- Article1
- Book1
- Book Digital1
- Article Type
- Clinical Trial1
- Clinical Study1
- Result From
- Lane Catalog1
- PubMed1
-
Year
- Journal Title
- Scand J Immunol1
Search Results
Sort by
- Bookedited by Dieter Steinhilber, editor.Summary: Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.
Contents:
Introduction into lipoxygenases
5-Lipoxygenase
Leukotriene A4 hydrolase and LTC4 synthase
Catalytic multiplicity of 15-lipoxygenase-1 orthologs (ALOX15) of different species
Platelets and lipoxygenases
Lipoxygenases and cardiovascular diseases
Role of lipoxygenases in pathogenesis of cancer
The physiology and pathophysiology of lipoxygenases in the skin
5-Oxo-ETE and inflammation
Lipoxins, resolvins, and the resolution of inflammation. - ArticleIvanyi L, Lehner T.Scand J Immunol. 1977;6(3):219-26.The effects of levamisole on gingival inflammation and on cell-mediated immunity were examined in patients with gingivitis and in subjects with clinically healthy gingiva. Treatment with levamisole promoted the development of gingivitis and aggravated the severity of established gingivitis, although the amount of bacterial plaque at the gingival margin was not significantly increased. This effect was short-lasting, as the gingival indices returned almost to base-line values by the end of the fifth month after treatment with levamisole. The development of gingivitis was associated with increased in vitro lymphocyte stimulation by antigens from oral bacteria. The role of cell-mediated immunity in the pathogenesis of gingival inflammation is discussed.