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  • Book
    Jean-Charles Preiser, editor.
    Summary: This book demonstrates how the latest insights into the physiopathology of the stress response can be integrated into clinical practice. The topic is particularly relevant since the metabolic changes triggered by acute stress, including adaptive responses such as resistance to anabolic signals, have recently been more precisely delineated. The underlying mechanisms of these changes are also now better understood. The authors analyse how these advances could result in better management and more effective prevention of the long-term clinical consequences of the alterations occurring during the acute phase. An international panel of respected experts discusses these topics and describes the management of some common clinical conditions.

    Contents:
    Foreword
    Introduction
    Part 1: Metabolic changes
    Successive phases
    Bioenergetics of the stress response
    Hibernation and mitochondrial adaptation
    Resistance to anabolic signals
    Use of lipids as energy substrates
    Use of carbohydrates
    Stress hyperglycemia
    Protein metabolism
    Micronutrients
    Part 2: Hormonal regulation
    Hypothalamic-pituitary axis
    Thyroid
    Adrenal
    Sex hormones
    Enterohormones
    Adipokines
    Part 3: Particular clinical situations
    Severe undernutrition
    Traumatic brain injury
    Sepsis and MOF
    Morbid obesity
    Burn injury.
    Digital Access Springer 2016
  • Article
    Brooks JB.
    Adv Chromatogr. 1977;15:1-31.
    Electron capture gas-liquid chromatography, when used to analyze derivatized extracts of spent culture media and body fluids under specified conditions, holds promise as a tool for use by physicians, hospitals, and clinical laboratories in identifying certain diseases and disease-producing organisms. The detection of certain disease processes and the identification of disease-producing organisms are based on qualitative or large quantitative differences in EC-GLC profiles or a combination of both. Various practical procedures are given for extracting and derivatizing compounds, such as carboxylic acids, hydroxy acids, alcohols, amines, and nitrosamines. The characteristics of the parameters essential for successful analysis are discussed. Species and, in some cases, strains have been differentiated by comparing EC-GLC profiles. Metabolic products are affected by change in substrate. Media that can be reproduced from lot to lot are essential in some studies. The volatile components detected by EC-GLC in spent culture media consist mostly of bacterial metabolites, but the volatile compounds detected in body fluids may be bacterial metabolites, volatile components produced by the host in response to an infection, metabolites of cells associated with host defense, or a combination of two or more of these groups of compounds. The EC-GLC profiles obtained by analysis of synovial and cerebrospinal fluids appear to have good potential for use in diagnosing certain forms of arthritis and meningitis. Well-documented samples are essential to establishing EC-GLC profiles representative of a particular disease. A moderately priced computer would greatly aid in data processing and could be especially useful in compensating for minor changes in the retention times of peaks, which can occur as a result of column aging or when columns are renewed. An approach to the identification of components detected by EC-GLC, which makes use of electron capture gas chromatography-mass spectrometry, is presented.
    Digital Access Access Options
  • Book
    By Philip P. Carpenter ... Embracing the second report made to the British association on this subject, with other papers; reprinted by permission, with a general index.
    Digital Access Full text via HathiTrust, 1872