BookJean-Charles Preiser, editor.
Summary: This book demonstrates how the latest insights into the physiopathology of the stress response can be integrated into clinical practice. The topic is particularly relevant since the metabolic changes triggered by acute stress, including adaptive responses such as resistance to anabolic signals, have recently been more precisely delineated. The underlying mechanisms of these changes are also now better understood. The authors analyse how these advances could result in better management and more effective prevention of the long-term clinical consequences of the alterations occurring during the acute phase. An international panel of respected experts discusses these topics and describes the management of some common clinical conditions.
Contents:
Foreword
Introduction
Part 1: Metabolic changes
Successive phases
Bioenergetics of the stress response
Hibernation and mitochondrial adaptation
Resistance to anabolic signals
Use of lipids as energy substrates
Use of carbohydrates
Stress hyperglycemia
Protein metabolism
Micronutrients
Part 2: Hormonal regulation
Hypothalamic-pituitary axis
Thyroid
Adrenal
Sex hormones
Enterohormones
Adipokines
Part 3: Particular clinical situations
Severe undernutrition
Traumatic brain injury
Sepsis and MOF
Morbid obesity
Burn injury.