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- Bookedited by Paul C. Barrow.Contents:
ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise
Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong
Developmental toxicity testing of biologics / Keith P. Hazelden
OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann
Teratology testing under REACH / Steve Barton
Teratology testing of food additives / Paul C. Barrow and Francois Spezia
Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais
Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow
Teratology studies in the rat / Mariline Leroy and Linda Allais
Teratology studies in the mouse / Edward Marsden and Mariline Leroy
Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden
Teratology studies in the rabbit / Linda Allais and Lucie Reynaud
Teratology studies in the minipig / Peter A. McAnulty
Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer
Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs
Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier
Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider
Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman
Fetal soft tissue examination by serial sectioning / Karon Critchell
Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier
Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse
Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris
Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud
Maternal toxicity / Bengt R. Danielsson
Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma
Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes
Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma
Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis
Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche
Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch
Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma
Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim
Regulatory assessment of reproductive toxicology data / Elizabeth Davidson
Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner
Reproductive toxicity risk assessment for pesticides / Beate Ulbrich
Thalidomide disaster, lessons from the past / James E. Ridings.Digital Access Springer 2013 - ArticleLiu C, Hinthorn DR, Hodges GR, Harms JL, Couchonnal G, Dworzack DL.Rev Infect Dis. 1979 Jan-Feb;1(1):127-31.Single, intravenously administered doses of cefoxitin and cefamandole did not penetrate into cerebrospinal fluid of normal humans. Multiple-dose administration with or without probenecid facilitated penetration of both antibiotics into the cerebrospinal fluid. Preliminary data showed that cefoxitin penetrated into cerebrospinal fluid of patients with inflamed meninges even when administered in a single dose without probenecid. However, the concentrations of cefoxitin in the cerebrospinal fluid of the individuals studied were not within the therapeutic range.