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  • Book
    volume editors, Jeremy Allgrove, Nick J. Shaw.
    Contents:
    Voyages of discovery / Allgrove, J.
    Physiology of calcium, phosphate, magnesium and vitamin D / Allgrove, J.
    Physiology of bone / Grabowski, P.
    Radiology of osteogenesis imperfecta, rickets and other bony fragility states / Calder, A.D.
    Bone densitometry : current status and future perspective / Crabtree, N.; Ward K.
    A practical approach to hypocalcaemia in children / Shaw, N.J.
    Approach to the child with hypercalcaemia / Davies, J.H.
    A practical approach to vitamin D deficiency and rickets / Allgrove, J.; Shaw, N.J.
    A practical clinical approach to pediatric phosphate disorders / Imel, E.A. ; Carpenter, T.O.
    Primary osteoporosis / Arundel, P. ; Bishop, N.
    Osteoporosis in children with chronic disease / Hgler, W. ; Ward, L.
    Genetics of osteoporosis in children / van Dijk, F.S.
    A practical approach to children with recurrent fractures / Korula, S.; Titmuss, A.T.; Biggin A.; Munns, C.F.
    Miscellaneous bone disorders / Mughal, M.Z.; Padidela, R.
    Skeletal aspects of non-accidental injury / Johnson, K.; Bradshaw, K.
    Skeletal dysplasias: an overview / Offiah, A.C
    Drugs used in paediatric bone and calcium disorders / Cheung, M.S.
    Classification of disorders of bone and calcium metabolism / Allgrove J.
    Case histories / Katugampola, H. ; Saraff, V.; Kumaran, A. ; Allgrove, J.; Shaw, N.J.
    Digital Access Karger 2015
  • Article
    Cohen JJ, Fairchild SS.
    Proc Natl Acad Sci U S A. 1979 Dec;76(12):6587-90.
    The activity of T lymphocyte precursors (pre-T cells) in the bone marrow of mice was measured by the concanavalin A response synergy assay. Pre-T cell levels were low in marrow of neonatally thymectomized mice and could be restored to control values by treatment in vivo with an extract of mouse thymus. Levels of activity were also low in aging mice and again could be restored by thymic extract treatment. The most profound fall with aging was in the proliferating pre-T cell compartment as detected by tritiated thymidine suicide; and this compartment was restored by thymic extract treatment. Irradiation to the thymus, with the bone marrow shielded, caused a fall in resting pre-T cells in the bone marrow and a concomitant rise in proliferating cells. These results are consistent with a model of control of pre-T cell maturation in which the thymus senses the number of developing lymphocytes within it and responds to a fall in this number by increasing production of hormone. The hormone acts on resting pre-T cells in the marrow, stimulating some of them to proliferate, leave the bone marrow, and repopulate the thymus.
    Digital Access Access Options