BookMoneeb Ehtesham, editor.
Summary: "This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control"--Publisher's description.
Contents:
Regulation of subventricular zone-derived cells migration in the adult brain
The SVZ and its relationship to stem cell based neuro-oncogenesis
Isolation and characterization of stem cells from human central nervous system malignancies
The role of stem cells in pediatric central nervous system malignancies
Laboratory models for central nervous system tumor stem cell research
Radiation therapy for glioma stem cells
Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma
Immunobiology and immunotherapeutic targeting of glioma stem cells
Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
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