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  • Book
    Lieuwe De Haan, Frederike Schirmbeck, Mathias Zink, editors.
    Summary: This book summarizes scientific advances in our understanding of the interrelationship between obsessive-compulsive symptoms (OCS) and schizophrenia and reflects on the implications for future research directions. In addition, guidelines are provided on practical assessment, diagnosis, and treatment interventions, covering both pharmacotherapy and psychotherapy. Full account is taken of the fact that the variable clinical presentation regarding time of onset and course of OCS in patients with schizophrenia strongly suggests the need for a perspective that recognizes heterogeneous subgroups and diverse neurobiological explanations. Research-based multidimensional conceptual frameworks are accordingly provided relating to the co-occurrence of the disorders, incorporating recent epidemiological, neurocognitive, neurogenetic, and pharmacodynamic findings. Obsessive-Compulsive Symptoms in Schizophrenia has been written by an international team of experts who offer insights gained through their extensive experience. It will be an invaluable guide to this frequent and clinically important comorbidity and will be particularly useful for mental health practitioners.

    From diagnostic entities to multidimensional concepts in psychiatry: Comorbid psychiatric disorders in Schizophrenia
    Comorbid psychiatric disorders in OCD: The Spectrum-Concept
    Phenomenology: Clinical presentation of OCS in patients with psychotic disorders (psychopathology, classification, diagnosis)
    Epidemiology: Dimensional overlap: Schizotypic OCD, schizo-obsessive disorder
    Associations of comorbid OCS with psychotic and affective symptoms and general functioning
    Neurobiology: The neurocognitive impact of comorbid OCS in schizophrenia
    GxE interactions in the pathogenesis of OCS in schizophrenia
    Neurophysiological and Neuroimaging results
    Effects of antipsychotic treatment on OCS
    Therapeutical interventions
    Augmentation and combination strategies
    Cognitive behavioural therapy
    Directions of further research.
    Digital Access Springer 2015