Bookeditor-in-chief, Michael A. Grippi ; co-editors, Jack A. Elias, Jay A. Fishman, Robert M. Kotloff, Allan I. Pack, Robert M. Senior ; video editor, Mark D. Siegel.
Contents:
Part 1: Perspectives. Milestones in the history of pulmonary medicine
Part 2: Scientific basis of lung function in health and disease. Genetic, cellular, and structural basis of normal lung function
Functional design of the human lung for gas exchange
The respiratory muscles
Molecular regulation of lung development
Pulmonary surfactant and disorders of surfactant homeostasis
The genetic basis of respiratory disorders
Stem cells and respiratory disease: prospects for the future
Personalized pulmonary medicine
Physiological principles of normal lung function
Pulmonary mechanics
Control of ventilation
Circadian rhythms and sleep biology
Pulmonary circulation
Ventilation, pulmonary blood flow, and ventilation-perfusion relationships
Blood-gas transport
Diffusion, chemical reactions, and diffusing capacity
Acid-base balance
The lungs in different physiological states
Respiratory system response to exercise in health
Aging of the respiratory system
Lung immunology
Innate and adaptive immunity in the lung
Lymphocyte- and macrophage-mediated inflammation in the lung
Mast cells and eosinophils
Leukocyte accumulation in pulmonary disease
Antibody-mediated lung defenses and humoral immunodeficiency
Lung injury and repair
T lymphocytes in the lung
Chemokines, adipokines, and growth factors in the lung
Redox signaling and oxidative stress in lung diseases
Fibroblasts in lung homeostasis and disease.