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  • Book
    edited by Anna Bal-Price, Paul Jennings.
    Summary: In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

    Contents:
    Machine generated contents note: pt. I Introduction
    1.The Past, Present, and Future of Chemical Risk Assessment / Alice Limonciel
    pt. II Systemic Organ Toxicity
    2.In Vitro Systems for Hepatotoxicity Testing / Patricio Godoy
    3.In Vitro Methods for Cardiotoxicity Testing / Agapios Sachinidis
    4.Renal Cell Culture / Gerhard Gstraunthaler
    5.Cellular Models for In Vitro Lung Toxicology / Oliver H. Wittekindt
    pt. III Neurotoxicity
    6.In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints / Helena T. Hogberg
    7.Blood
    Brain Barrier In Vitro Models and Their Applications in Toxicology / Maxime Culot
    pt. IV Sensory Organ Models
    8.Ocular Toxicity / Valerie Zuang
    9.In Vitro Models for Ototoxic Research / Michael G. Leitner
    pt. V Other Organs and Aspects
    10.Dermal Toxicity: Skin Sensitization / Silvia Casati
    11.Immunotoxicity / Thomas Hartung
    12.Reproductive Toxicity / Cesare Galli --
    Digital Access Springer 2014
  • Article
    Janik JS, Firor HV.
    Arch Surg. 1979 Jun;114(6):717-9.
    Of 1,640 children with acute appendicitis treated at Cook County (Illinois) Hospital between Jan 1, 1957, and Dec 31, 1976, 35% had appendiceal perforation. Overall morbidity was 12.8% and mortality was 0.24%. Antibiotics, transperitoneal drainage, and delayed wound closure were used routinely in children with appendiceal perforation. Antibiotics and transperitoneal drains did not appreciably alter the incidence of intraabdominal abscess formation. Delayed wound closure in patients with appendiceal perforation reduced the incidence of wound infection by 75%.
    Digital Access Access Options