Bookedited by Anna Bal-Price, Paul Jennings.
Summary: In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
Contents:
Machine generated contents note: pt. I Introduction
1.The Past, Present, and Future of Chemical Risk Assessment / Alice Limonciel
pt. II Systemic Organ Toxicity
2.In Vitro Systems for Hepatotoxicity Testing / Patricio Godoy
3.In Vitro Methods for Cardiotoxicity Testing / Agapios Sachinidis
4.Renal Cell Culture / Gerhard Gstraunthaler
5.Cellular Models for In Vitro Lung Toxicology / Oliver H. Wittekindt
pt. III Neurotoxicity
6.In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints / Helena T. Hogberg
7.Blood
Brain Barrier In Vitro Models and Their Applications in Toxicology / Maxime Culot
pt. IV Sensory Organ Models
8.Ocular Toxicity / Valerie Zuang
9.In Vitro Models for Ototoxic Research / Michael G. Leitner
pt. V Other Organs and Aspects
10.Dermal Toxicity: Skin Sensitization / Silvia Casati
11.Immunotoxicity / Thomas Hartung
12.Reproductive Toxicity / Cesare Galli --