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  Brain metastases from primary tumors : epidemiology, biology, and therapy. Volume I

  edited by M.A. Hayat.

  Summary: With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. This volume fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types -- lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection.
  
  Contents:
  Brain metastases
  Epidemiology of central nervous system metastases
  Involvement of the CXCL12/CXCR4/CXCR7 axis in brain metastases
  Non-uniform distribution of metastatic intracranial tumors in cancer patients
  Targeting angiogenesis, enhancing radiosensitization and crossing the blood-brain barrier for brain metastases
  Second malignancies in children following treatment for neuroblastoma
  The role of chemotherapy in metastatic brain tumors
  Multiple metastases to the brain from primary cancers : whole brain radiotherapy
  Synovial sarcoma metastasized to the brain
  Multiple small brain metastases with limited focal brain edema from non-small cell lung cancer with epidermal growth factor receptor mutations
  Brain metastasis of patients with lung adenocarcinoma : epidermal growth factor receptor mutations and response to whole-brain radiation therapy
  Metastatic spread of lung cancer to brain and liver : role of CX3CR1
  Solitary brain metastasis from non-small cell lung cancer : treatment with linac-based stereotactic radiosurgery
  Brain metastases from non-small cell lung cancer : clinical benefits of erlotinib and gefitinib
  Bispecific targeted toxin DTATEGF against metastatic NSCLC brain tumors
  Intracranial disease in patients with non-small cell lung cancer : treatment with erlotinib
  Radiation management of synchronous brain metastases from non-small cell lung cancer
  Brain metastasis after prophylactic cranial irradiation in patients with small cell lung cancer
  Brain metastasis from small-cell lung cancer with high levels of placental growth factor
  Brain metastases from lung cancer
  Lambert-Eaton myesthenic syndrome and brain metastasis from occult small cell lung carcinoma : a clinician's perspective.

  Digital Access ClinicalKey v. 1, 2014
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• Article

  Pulmonary cavitation and Pi SZ alpha1-antitrypsin deficiency.

  Rosenfeld S, Granoff DM.

  J Pediatr. 1979 May;94(5):768-70.

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  PubMed