Bookedited by M.A. Hayat.
Summary: With an annual rate of more than 12 million global diagnoses and 7.6 million deaths, the societal and economic burden of cancer cannot be overstated. Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. This volume fills that gap, serving as the first reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types -- lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age and gender related trends are also discussed, as is the use of biomarkers for early detection.
Contents:
Brain metastases
Epidemiology of central nervous system metastases
Involvement of the CXCL12/CXCR4/CXCR7 axis in brain metastases
Non-uniform distribution of metastatic intracranial tumors in cancer patients
Targeting angiogenesis, enhancing radiosensitization and crossing the blood-brain barrier for brain metastases
Second malignancies in children following treatment for neuroblastoma
The role of chemotherapy in metastatic brain tumors
Multiple metastases to the brain from primary cancers : whole brain radiotherapy
Synovial sarcoma metastasized to the brain
Multiple small brain metastases with limited focal brain edema from non-small cell lung cancer with epidermal growth factor receptor mutations
Brain metastasis of patients with lung adenocarcinoma : epidermal growth factor receptor mutations and response to whole-brain radiation therapy
Metastatic spread of lung cancer to brain and liver : role of CX3CR1
Solitary brain metastasis from non-small cell lung cancer : treatment with linac-based stereotactic radiosurgery
Brain metastases from non-small cell lung cancer : clinical benefits of erlotinib and gefitinib
Bispecific targeted toxin DTATEGF against metastatic NSCLC brain tumors
Intracranial disease in patients with non-small cell lung cancer : treatment with erlotinib
Radiation management of synchronous brain metastases from non-small cell lung cancer
Brain metastasis after prophylactic cranial irradiation in patients with small cell lung cancer
Brain metastasis from small-cell lung cancer with high levels of placental growth factor
Brain metastases from lung cancer
Lambert-Eaton myesthenic syndrome and brain metastasis from occult small cell lung carcinoma : a clinician's perspective.