BookRichard W. Compans, Michael B.A. Oldstone, editors.
Summary: This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
Contents:
The Hemagglutinin
a Determinant of Pathogenicity
Molecular determinants of pathogenicity in the polymerase complex
Receptor binding properties of the influenza virus hemagglutinin as a determinant of host range
Acid-induced membrane fusion by the hemagglutinin protein and its role in influenza virus biology
Pandemic Preparedness and the Influenza Risk Assessment Tool (IRAT)
Avian influenza virus transmission to mammals
Transmission in the Guinea Pig Model
Enhancement of influenza virus transmission by gene reassortment
Swine and Influenza: A Challenge to One Health Research
Influenza Pathobiology and Pathogenesis in Avian Species
Molecular determinants of influenza virus pathogenesis in mice
Mammalian models for the study of H7 virus pathogenesis and transmission
Pathogenesis and vaccination of influenza A virus in swine
Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis
Evolution and Ecology of Influenza A viruses
Influenza A virus reassortment
Antigenic Analyses of Highly Pathogenic Avian Influenza A Viruses.
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