Bookvolume editor, Kevan M. Shokat.
Contents:
Catalytic mechanisms and regulation of protein kinases / Zhihong Wang and Philip A. Cole
A structural atlas of kinases inhibited by clinically approved drugs / Qi Wang, Julie A. Zorn, and John Kuriyan
Fragment-based approaches to the discovery of kinase inhibitors / Paul N. Mortenson, Valerio Berdini, and Marc O'Reilly
Targeting protein kinases with selective and semi-promiscuous covalent inhibitors / Rand M. Miller and Jack Taunton
The resistance tetrad: amino acid hotspots for kinome-wide exploitation of drug-resistant protein kinase alleles / Fiona P. Bailey, Veselin I. Andreev, and Patrick A. Eyers
FLiK: a direct binding assay for the identification and kinetic characterization of stabilizers of inactive kinase conformations / Jeffrey R. Simar and Daniel Rauh
Discovery of allosteric BCR-ABL inhibitors from phenotypic screen to clinical candidate / Nathanael S. Gray and Doriano Fabbro
The logic and design of analog-sensitive kinases and their small molecule inhibitors / Michael S. Lopez, Joseph I. Kliegman, and Kevan M. Shokat.