BookJerry L. Workman, Susan M. Abmayr, editors.
Summary: Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. It is essential for packaging DNA, regulation of gene expression, DNA replication and repair. The audience for this book includes newly established scientists, graduate students and scientists seeking detailed overviews of various aspects of chromatin structure and function to gain entry into this field. The chapters in this book give a strong, updated groundwork about the fundamentals of chromatin which are essential to understand epigenetics. Some the fundamentals that this book covers include the structure and biochemistry of chromatin and the enzyme complexes that manage it.
Contents:
Preface
Histone, Nucleosome and Chromatin Structure
Histone Chaperones in the Assembly and Disassembly of Chromatin
Chromatin Remodeling Complexes
Regulating Chromatin by Histone Acetylation
Histone Methylation in Chromatin Signaling
Histone Ubiquitylation Control of Gene Expression
Regulation of Chromatin Structure and Function by PARP-1 and ADP-ribosylation
Histone phosphorylation and chromatin dynamics
Reading histone modifications
Properties and functions of histone variants
Transcription through Chromatin
Chromatin remodeling in DNA repair and replication
Heterochromatin: A Critical Part of the Genome
Emerging Areas of Chromatin Research
Index.