BookPhilip C. Burcham.
Summary: This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960?s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that "unpack" the concepts being discussed in the text.
Contents:
The Emergence of Modern Toxicology
Core Concepts in Toxicology
Toxicokinetics : The Fate of Chemicals within the Body
Toxicodynamics : How Chemicals Induce Toxicity
Fightback : Adaptive Responses to Toxicant Exposure
Target Organ Toxicity: Liver and Kidney
Chemical Toxicity to the Unborn
Chemicals and Cancer
Everyday Toxicology I : Alcohol
Everyday Toxicology II: Tobacco.