Bookedited by Shizuya Saika, Liliana Werner, Frank J. Lovicu.
Summary: This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to arise during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule. The first section of the text explains the molecular mechanism and biology of lens epithelial cells that lead to the incidence of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.
Contents:
PART I: Lens Epithelial Cell Biology
Chapter 1. From Zygote to Lens: Emergence of the Lens Epithelium
Chapter 2. Cell Biology of Lens Epithelial Cells
Chapter 3. The Lens Capsule
Synthesis, Remodeling and MMPs
Chapter 4. Lens Epithelial Cell Proliferation
Chapter 5. Growth Factor Signaling in Lens Fiber Differentiation
Chapter 6. Lens-Specific Transcription Factors and Their Roles in Diagnosis and Treatment of Human Congenital Cataract
Chapter 7. Lens Regeneration
Chapter 8. Fibrotic Modifications of the Lens Epithelium
Chapter 9. Wound Healing and Epithelial-Mesenchymal Transition in the Lens Epithelium: Roles of Growth Factors and Extracellular Matrix
Part II: Clinical Science -Pathology
Chapter 10. Histology of Posterior Capsular Opacification
Chapter 11. PCO Rates in a Large Series of Human Eyes Obtained Post-Mortem
Part III: Clinical Outcomes
Chapter 12. Natural Course of Elschnig Pearl Formation and Disappearance
Chapter 13. Effect of Posterior Capsule Opacification and Anterior Capsule Contraction on Visual Function
PART IV: Surgical Methods for PCO Prevention
Chapter 14. Size of Continuous Curvilinear Capsulorhexis for Prevention of PCO
Chapter 15. Effect of Anterior Capsule Polishing on Capsule Opacification and YAG Laser Capsulotomy
Chapter 16. Laser Photolysis System and PCO Prevention
PART V: Intraocular Lenses/Devices and PCO
Chapter 17. PCO Prevention: IOL Material Versus IOL Design
Chapter 18. Capsular and Uveal Biocompatibility of Different IOLs in Eyes with and Without Associated Conditions
Chapter 19. Capsule-Bending Ring for the Prevention of Posterior Capsule Opacification
Chapter 20. PCO Prevention with Endocapsular Equator Rings
Chapter 21. PCO Prevention with IOLs Maintaining an Open or Expanded Capsular Bag
Chapter 22. Prevention of PCO with the Bag-in-the-lens (BIL)
Chapter 23. Posterior capsule Opacification with Micro incision (MICS) IOLs
PART VI: Special Cases
Chapter 24. PCO and the Pediatric Eye.