BookToru Nakazawa, Yasushi Kitaoka, Takayuki Harada, editors.
Summary: This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa. Glaucoma is one of the main causes of blindness throughout the world, and other diseases such as AMD and retinitis pigmentosa also lead to loss of vision. All these conditions are characterized by degeneration of specific retinal cell types, making it essential to establish treatments to protect retinal neurons and the optic nerve. With that aim in mind, this book explains the mechanisms underlying aforementioned diseases and their experimental models. The novel strategy proposals for the treatment of retinal diseases based on the concept of neuroprotection are also discussed in the main body of the text, while the section on regenerative research discusses optic nerve regeneration, endothelial progenitor cells, and iPS cells. This book is recommended as a professional reference work for all doctors and trainees in the field of ophthalmology who are interested in neuroprotective and neuroregenerative treatments.
Contents:
Part I Neuroprotection for Glaucoma
1. Molecular Architecture of Glutamate Signaling Pathway in Glaucomatous Optic Neuropathy
2. Calcium and Calpain Activation
3. Classical Signaling Pathways
4. Antioxidative Treatment for Neuroprotection in Glaucoma
5. ER stress
6. Nitric Oxide Contributes to Retinal Ganglion Cell Survival Through Protein S-Nitrosylation after Optic Nerve Injury
7. Neurotrophic factors
8. RIP Kinase-Mediated Programmed Necrosis
9. Axonal Degeneration
10. Axonal Transport
11. Interaction Between RGC Bodies and Glia
12. Aquaporin in optic neuropathies
13. Microglia
Part II Neuroprotection for Age-Related Macular Degeneration (AMD), Retinal Pigmentary Degeneration
14. Neuroprotection for Photoreceptors
15. Retinal Photooxidative Stress and Its Modifiers
16. Roles of the Retinal Pigment Epithelium in Neuroprotection
17. Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis; Implication of Light Exposure
18. Interaction Between Photoreceptors and RPEs
Part III Neuroprotection for Other Retinal Diseases
19. Neuroprotection for Retinal Detachment
20. Neuroinflammation
21. Optic Neuritis
22. Neuroprotection by Endothelial Progenitor Cells for Retinal Degeneration
23. Optic Nerve Regeneration.