BookAndrea Aliverti, Antonio Pedotti, editors.
Summary: This book offers a state-of-the-art description of the complexity of the healthy and pathological respiratory system, with particular reference to the mechanics of the airways, lung and chest wall. Detailed information is provided on new insights into the mechanics of breathing that have been obtained through technological innovations in measurement systems, cutting-edge modeling techniques and novel approaches to functional imaging of the respiratory system. It is explained how these advances permit the assessment of emerging treatment approaches, including new drugs, innovative surgical techniques and modes of mechanical ventilation and new forms of rehabilitation. In order to ensure comprehensive coverage of the subject, the editor has assembled a multidisciplinary team of authors comprising basic scientists in respiratory medicine, chest and intensive care physicians and bioengineers involved in both modeling and instrumentation. The book is intended for intensive care physicians, respirologists, physiologists, rehabilitation specialists, basic scientists in respiration, research and clinical fellows, biomedical engineers involved with respiratory mechanics and respiratory therapists. They will update their knowledge and improve their clinical expertise.
Contents:
The Act of Breathing
Work of Breathing During Exercise: Implications for Performance
Pathology of COPD and Asthma
Pathophysiology of Airflow Obstruction
Role of Airway Smooth Muscle Mechanical Properties in the Regulation of Airway Caliber
Nitric Oxide in Asthma Is Like Insulin in Type II Diabetes
Static and Dynamic Hyperinflation in Chronic Obstructive Pulmonary Disease
Lung Recruitment and De-recruitment
Lung Function Testing, Spirometry, Diffusion Capacity and Interpretation
Forced Oscillation Technique
Optoelectronic Plethysmography: Principles of Measurements and Recent Use in Respiratory Medicine
Respiratory Muscle Blood Flow Measured by Near-Infrared Spectroscopy (NIRS) and Indocyanine Green Dye (ICG)
Assessment of Dyspnoea
Noninvasive Measures of Lung Structure and Ventilation Heterogeneity
Computed Tomography (CT)-Based Analysis of Regional Lung Ventilation
Functional Imaging of Airway Distensibility
Function and Microstructure by Hyperpolarized Gas MRI
Pulmonary Functional Imaging with Positron Emission Tomography
Pharmacological Treatment: an Update
Respiratory and Non-respiratory Muscle Dysfunction in COPD
Pathophysiology of Chronic Obstructive Pulmonary Disease
Old and New Trends in Invasive Mechanical Ventilation
Use of Respiratory Mechanics for Monitoring and Setting of Noninvasive Mechanical Ventilation
Use of FOT for Optimising Mechanical Ventilation.