Today's Hours: 8:00am - 8:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Book
    Susan C. Frost, Robert McKenna, editors.
    Summary: The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification.

    Contents:
    Overview of the Carbonic Anhydrase Field
    Physiological Functions of the Alpha Class of Carbonic Anhydrases
    Catalytic Mechanism of [alpha]-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer
    Structure and Catalytic Mechanism of b-Carbonic Anhydrases
    Prokaryotic Carbonic Anhydrases of Earth?s Environment
    Carboxysomal Carbonic Anhydrases
    Carbonic Anhydrases and their Interplay with Acid/base-coupled Membrane Transporters
    Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution
    Membrane Associated Carbonic Anhydrase IV (CA IV): A Personal and Historical Perspective
    Carbonic Anhydrase Expression in Kidney and Renal Cancer: Implications for Diagnosis and Treatment
    Carbonic Anhydrase IX: Regulation and Role in Cancer
    Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases
    Carbonic Anhydrase IX (CAIX) as a Mediator of Hypoxia-induced Stress Response in Cancer Cells
    Carbonic Anhydrases and Brain pH in the Control of Neruronal Excitability
    Carbonic Anhydrase Inhibitors: Drug Design
    Natural Products that Inhibit Carbonic Anhydrases
    Glaucoma and the Application of Carbonic Anhydrase Inhibitors
    Carbonic Anhydrase Inhibitors and High Altitude Illnesses
    Thermal-Stable Carbonic Anhydrases: A Structural Overview
    Carbonic Anhydrases in Industrial Applications.
    Digital Access Springer 2014
  • Article
    Callaghan M, Sternbach RA, Nyquist JK, Timmermans G.
    Pain. 1978 Aug;5(2):115-127.
    Patients with chronic pain in one limb, who experienced pain reduction with transcutaneous neurostimulation, were examined for sensory perception in that limb before and during electrical analgesia. Contralateral limbs and normal subjects served as controls. Sensory stimuli were quantified, a range of stimuli were presented and data were analyzed according to sensory decision theory. Results showed that, compared to controls, painful limbs show considerable impairment in sensory sensitivity. With transcutaneous neurostimulation, however, sensitivity is improved towards normal, whereas electrical stimulation slightly impairs perception in normal limbs. These results suggest that electrical analgesia involves both peripheral small-fiber blockade and large-fiber stimulation; the latter is more noticeable in the normal limb, but the former effect is predominant when pain reduction occurs in a painful limb.
    Digital Access Access Options