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- Bookedited by Inna Belfer, Luda Diatchenko.Contents:
How do pain genes affect pain experience? / Marshall Devor
Conservation of pain genes across evolution / Thang Manh Khuong and G. Greg Neely
Defining human pain phenotypes for genetic association studies / Christopher Sivert Nielsen
Genetic contributions to pain and analgesia : interactions with sex and stress / Roger B. Fillingim and Jeffrey S. Mogil
Monogenic pain disorders / Geoff Woods
Alternative pre-mRNAsplicing of mu opioid receptor gene: molecular mechanisms underlying the complex actions of mu opioids / Ying-Xian Pan
Discovering multi-locus associations with complex pain phenotypes / Chia-Ling Kuo, Luda Diatchenko, Dmitri Zaykin
Overlapping phenotypes : genetic contribution to nausea and pain / Charles C. Horn
A counterpart to pain : itch / Adam P. Kardon and Sarah E. Ross
Translating genetic knowledge into clinical practice for musculoskeletal pain conditions / Luda Diatchenko, Shad B. Smith, William Maixner
The human chronic pain phenome : mapping non-genetic modifiers of the heritable risk / Ze'ev Seltzer, Scott R. Diehl, Hance Clarke and Joel Katz.Digital Access Wiley 2014 - ArticleGralnick HR.J Clin Invest. 1978 Aug;62(2):496-9.The normal Factor VIII/von Willebrand factor protein has the ability to agglutinate or aggregate normal platelets in the presence of ristocetin (von Willebrand factor activity). Removal of greater than 95% of the sialic acid from this protein by neuraminidase did not affect the von Willebrand factor or procoagulant activity. However, oxidation of the penultimate galactose of the asialo Factor VIII/von Willebrand factor protein with galactose oxidase resulted in a progressive loss of von Willebrand factor activity with no effect on procoagulant activity. Reduction of the 6-aldehydo intermediate by potassium borohydride caused full regeneration of von Willebrand factor activity. These studies confirm the identification of the intact penultimate galactose moiety as a critical determinant of von Willebrand factor activity.