BookSrinivasan Venkataramanujam, Amnon Brzezinski, Sukru Oter, Samuel D. Shillcutt, editors.
Summary: The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This bookcontains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinsons disease, Alzheimers disease. Additionally, melatonins therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonins antioxidant role in Duchennes muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.
Contents:
Melatonin Receptors and Their Role in Human Diseases
Melatonins Antioxidant Properties: Molecular Mechanisms
Past, Present and Future of Melatonins Clinical Uses
Melatonin in Human Cancer: Therapeutic Possibilities
Melatonin: Its Microbicidal Properties and Clinical Applications
Melatonin and the Metabolic Syndrome
Development of Agonists and Antagonists for Melatonin Receptors
Multiple Facets of Melatonin in Immunity: Clinical Applications
Melatonin and Immune Function: Clinical Significance
Circadian Variation of Immune Mechanisms in Lung Cancer and the Role of Melatonin
Melatonin and Melatonergic Drugs for Therapeutic Use in Breast Cancer
Melatonin and Malaria: Therapeutic Avenues
Melatonin's role in human reproduction: recent studies
Melatonin Treatment and Fertility
Melatonin and Pain: Therapeutic Applications
Melatonin in Alzheimers disease: Focus on Neuroprotective Role
Melatonin in Parkinsons disease and its Therapeutic Potential
Melatonin and Its Agonists in Sleep Disorders
Agomelatine in Depressive Disorders
Melatonin in Mood Disorders and Agomelatines Antidepressant Efficacy
The Role of Agomelatine in the Treatment of Anxiety Disorders .- Melatonin in the Etiology, Pathophysiology, and Management of Schizophrenia
Neurobiology of Monoaminergic Neurotransmission and Antidepressants
Melatonergic Drug - Ramelteon and Its Therapeutic Applications in Insomnia
Melatonins Neuroprotective Actions on Hippocampal Neurons
Jet Lag: Use of Melatonin and Melatonergic Drugs
Sleep, Melatonin and Circadian Rhythmicity in Attention Deficit Hyperactivity Disorder
Melatonergic Drugs and Their Therapeutic Use in Nasal Polyposis
Protective Effects of Exogenous Melatonin Against Methotrexate- Induced Intestinal Injury.