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  • Book
    Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam, editors.
    Summary: "Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance"--Publisher's description.

    Contents:
    Wellness and Health Omics Linked to the Environment: the WHOLE approach to personalized medicine
    Characterizing Multi-omic Data in Systems Biology
    High-throughput Translational Medicine: Challenges and Solutions
    Computational approaches for human disease gene prediction and ranking
    A Personalized Treatment for Lung Cancer: Molecular Pathways, Targeted Therapies, and Genomic Characterization-- Index.
    Digital Access Springer 2014
    Access via Advances in experimental medicine and biology ; 2014; 799
    Location
    Version
    Call Number
    Items
    Advances in experimental medicine and biology ; 2014; 799
    2014
  • Article
    Drongelen W.
    J Physiol. 1978 Apr;277:423-35.
    1. Receptor cell activity in the frog's eminentia olfactoria was recorded using metal-filled micro-electrodes. 2. Several units discharged spontaneously with a mean frequency lower than 0.2 spikes per sec, or were silent in periods of up to 5 min. The other units displayed spontaneous activities between 0.2 and 1.05 spikes per sec; their activity could be modelled with a Poisson process. 3. Near-threshold responses to odour stimulation were investigated, considering several stimulations within a small concentration range. Low concentration stimulations were sometimes followed by a response, sometimes not. The concept of response probability is introduced to describe this incertitude. 4. The distribution of the number of spikes in several odour trials at low concentrations showed a reasonable agreement with two types of Poisson distribution. 5. The findings are discussed in connexion with receptor cell sensitivity and the excitation of second order neurones in the bulb.
    Digital Access Access Options