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• Book

  The Evolution of the use of mathematics in cancer research

  Pedro J. Gutiérrez Diez, Irma H. Russo, Jose Russo.

  Contents:
  Historical Introduction
  Descriptive Biostatistics
  Inferential Biostatistics (I): Estimating Values of Biomedical Magnitudes
  Inferential Biostatistics (II): Estimating Biomedical Behaviors
  Equations: Formulating Biomedical Laws and Biomedical Magnitudes
  Systems of Equations: The Explanation of Biomedical Phenomena (I). Basic Questions
  Systems of Equations: The Explanation of Biomedical Phenomena (II). Dynamic Interdependencies
  Optimal Control Theory: From Knowledge to Control (I). Basic Concepts
  Optimal Control Theory: From Knowledge to Control (II). Biomedical Applications
  Game Theory.

  Digital Access Springer 2012
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• Article

  Ribonucleoprotein (RNP) soluble nuclear antigen: demonstration of its reaction with serum antibodies by counter-immunoelectrophoresis and further partial characterization.

  Peltier AP, Aussel C, Haim T, Cyna L.

  J Immunol Methods. 1977;16(2):153-63.

  The soluble ribonucleoprotein nuclear antigen reactive with specific antibodies present in sera from patients with Mixed Connective Tissure disease has alpha 2-beta 1 electrophoretic mobility, thus enabling its reaction with specific serum antibodies to be studied by counter-immunoelectrophoresis. Its molecular weight determined by elution from a calibrated Sephadex G-200 gel column is about 175,000. Its purification has been attempted by successive DEAE cellulose chromatography, Sephadex G-200 gel filtration and Hydroxyapatite chromatography. Polyacrylamide gel electrophoresis of RNP antigen-containing fractions showed persistent heterogeneity which could be due either to inadequate purification or to dissociation of the RNP-antigen during electrophoresis.

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  PubMed