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  • Book
    edited by Carlos López-Larrea.
    Contents:
    The origin of the bacterial immune response / Jesús Martínez Borra, Segundo González, and Carlos López Larrea
    The evolution of self during the transition to multicellularity / Aurora M. Nedelcu
    Glyconectin glycans as the self assembling nano-molecular-velcrosystem mediating self-nonself recognition and adhesion implicated in evolution of multicellularity / Gradimir N. Misevic, Nikola Misevic, and Octavian Popescu
    Neglected biological features in cnidarians self-nonself recognition / Baruch Rinkevich
    Intracellular inflammatory sensors for foreign invaders and substances of self-origin / Nao Jounai, Kouji Kobiyama, and Fumihiko Takeshita
    Nonself perception in plant innate immunity / Ian A. Dubery, Natasha M. Sanabria, and Ju Chi Huang
    How did flowering plants learn to avoid blind date mistakes? : self-incompatibility in plants and comparisons with nonself rejection in the immune response / Philip J. Kear and Bruce McClure
    Signaling pathways that regulate life and cell death : evolution of apoptosis in the context of self-defense / Cristina Muñoz Pinedo
    Sensing necrotic cells / Yasunobu Miyake and Sho Yamasaki
    Sensing endoplasmic reticulum stress / Vipul M. Parmar and Martin Schröder
    Autophagy and self-defense / Jesús Martínez-Borra and Carlos López-Larrea
    Viruses and host evolution : virus-mediated self identity / Louis Villarreal
    The evolution of adaptive immunity / Nadia Danilova
    Epigenetic code and self-identity / Vincanzo Calvanese, Ester Lara and Mario F. Fraga
    Viral immunomodulatory proteins : usurping host genes as a survival strategy / Pablo Engel and Ana Angulo
    The emergence of the major histocompatibility complex / Jesús Martínez-Borra and Carlos López-Larrea
    MHC signaling during social communication / James S. Ruff ... [et al.].
    Digital Access Springer 2012
    Access via Advances in experimental medicine and biology ; 2012; 738
    Location
    Version
    Call Number
    Items
    Advances in experimental medicine and biology ; 2012; 738
    c2012
  • Article
    Regalado RG.
    J Int Med Res. 1977;5(1 Suppl):72-7.
    Forty-six patients were admitted to an open general practice study of clomipramine (Anafranil) in the treatment of long-standing rheumatic pain; forty-one patients completed the trial. The duration of the trial was 56 days during which patients received daily doses of either 10 mg or 25 mg of clomipramine. Assessments were made at fortnightly intervals. Patients were assessed for pain using a visual analogue scale, analgesic requirement, joint pain, other pain and morning stiffness. At the completion of the study patients were asked whether the addition of clomipramine to their treatment was better, the same or worse than no additional treatment. Twenty-one patients (57%) felt that it was better, four felt that it was the same and twelve said that it was worse. The doctor also similarly recorded his preference at the end of the trial. In twenty-two cases (60%) the doctor felt it was better, in eight that there was no difference and in seven that it was worse. There was no difference between the 10 mg and the 25 mg regime. It is suggested that better control of rheumatic symptoms can be achieved in some patients by the addition of small daily doses of clomipramine to their standard anti-rheumatic therapy. The author expresses the view that further research in this field is merited.
    Digital Access Access Options