BookStephen Neidle.
Summary: "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. 4 of cover.
Contents:
Introduction : quadruplexes and their biology
DNA and RNA quadruplex structures
The structures of human telomeric DNA quadruplexes
Telomeric quadruplex ligands I : anthraquinones and acridines
Telomeric quadruplex ligands II : polycyclic and non-fused ring compounds
The biology and pharmacology of telomeric quadruplex ligands
Genomic quadruplexes as therapeutic targets
RNA quadruplexes
Design principles for quadruplex-binding small molecules
The determination of quadruplex structures.