Anatomy and Normal Histology of the Prostate Pertinent to Biopsy Practice -- Prostate Needle Biopsy Sampling Techniques: Impact on Pathological Diagnosis -- Diagnosis of Limited Cancer in Prostate Biopsy -- Immunohistochemistry in Prostate Biopsy Evaluation -- Contemporary Approach to Gleason Grading of Prostate Cancer -- Histologic Variants of Prostate Carcinoma -- Benign Mimics of Prostate Carcinoma -- Atypical Cribriform Lesions of the Prostate Gland: Emerging Concepts of Intraductal Carcinoma of the Prostate (IDC-P) -- High-Grade Prostatic Intraepithelial Neoplasia -- Atypical Glands Suspicious for Cancer -- Spindle Cell Lesions of the Prostate Gland -- Treatment Effect in Benign and Malignant Prostate Tissue -- Molecular Biology of Prostate Cancer and Emerging Diagnostic and Prognostic Biomarkers -- Biopsy Specimen Handling, Processing, Quality Assurance Program -- Reporting of Prostate Biopsy.