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- ArticleKwon S, Seoung D, Jung E, Park J, Lim J, Park B, Cho Y, Kim P, Kim H, Lee Y.Chemosphere. 2024 Apr;353:141510.Biotite, a phyllosilicate mineral, possesses significant potential for cesium (Cs) adsorption owing to its negative surface charge, specific surface area (SSA), and frayed edge sites (FES). Notably, FES are known to play an important role in the adsorption of Cs. The objectives of this study were to investigate the Cs adsorption capacity and behavior of artificially weathered biotite and identify mineralogical characteristics for the development of an eco-friendly geologically-based Cs adsorbent. Through various analyses, it was confirmed that the FES of biotite was mainly formed by mineral structural distortion during artificial weathering. The Cs adsorption capacity is improved by approximately 39% (from 20.53 to 28.63 mg g-1) when FES are formed in biotite through artificial weathering using a low-concentration acidic solution mixed with hydrogen peroxide (H2O2). Especially, the Cs selectivity in Cs-containing seawater, including high concentrations of cations and organic matter, was significantly enhanced from 203.2 to 1707.6 mL g-1, an increase in removal efficiency from 49.5 to 89.2%. These results indicate that FES of artificially weathered biotite play an essential role in Cs adsorption. Therefore, this simple and economical weathering method, which uses a low-concentration acidic solution mixed with H2O2, can be applied to natural minerals for use as Cs adsorbents.
- ArticleHuang Q, Wen T, Fang T, Lao H, Zhou X, Wei T, Luo Y, Xie C, Huang Z, Li K.Food Chem. 2025 Jan 15;463(Pt 4):141510.The sugarcane tip is abundant in phenolic compounds. Previous studies have concentrated on the effects of free polyphenols, while bound polyphenols were overlooked. In this study, the content of bound polyphenols (SPB) (31.9 ± 0.9 mg GAE/g DW) was significantly higher than free polyphenols (SPF) (3.4 ± 0.1 mg GAE/g DW). A total of 44 free and 31 bound phenolics were identified by the UPLC-EIS-QTOF-MS/MS. Moreover, the antioxidant activity of SPB was more pronounced, as evidenced by its higher ABTS+ and DPPH scavenging rates than SPF, which was attributed to the higher tannin content. Furthermore, at all tested concentrations (100 and 200 μg/mL), SPB significantly enhanced the survival and antioxidant enzyme activity of Caenorhabditis elegans (C. elegans), while concurrently reducing ROS levels. High concentrations of SPB even exhibited antioxidant activity comparable to Vitamin C (Vc). The collective findings strongly indicate that SPB holds great potential as an effective antioxidant.
- ArticleLarmuseau MH, Vessi A, Jobling MA, Van Geystelen A, Primativo G, Biondi G, Martínez-Labarga C, Ottoni C, Decorte R, Rickards O.PLoS One. 2015;10(11):e0141510.Patterns of genetic variation in human populations across the African continent are still not well studied in comparison with Eurasia and America, despite the high genetic and cultural diversity among African populations. In population and forensic genetic studies a single sample is often used to represent a complete African region. In such a scenario, inappropriate sampling strategies and/or the use of local, isolated populations may bias interpretations and pose questions of representativeness at a macrogeographic-scale. The non-recombining region of the Y-chromosome (NRY) has great potential to reveal the regional representation of a sample due to its powerful phylogeographic information content. An area poorly characterized for Y-chromosomal data is the West-African region along the Bight of Benin, despite its important history in the trans-Atlantic slave trade and its large number of ethnic groups, languages and lifestyles. In this study, Y-chromosomal haplotypes from four Beninese populations were determined and a global meta-analysis with available Y-SNP and Y-STR data from populations along the Bight of Benin and surrounding areas was performed. A thorough methodology was developed allowing comparison of population samples using Y-chromosomal lineage data based on different Y-SNP panels and phylogenies. Geographic proximity turned out to be the best predictor of genetic affinity between populations along the Bight of Benin. Nevertheless, based on Y-chromosomal data from the literature two population samples differed strongly from others from the same or neighbouring areas and are not regionally representative within large-scale studies. Furthermore, the analysis of the HapMap sample YRI of a Yoruban population from South-western Nigeria based on Y-SNPs and Y-STR data showed for the first time its regional representativeness, a result which is important for standard population and forensic genetic applications using the YRI sample. Therefore, the uniquely and powerful geographical information carried by the Y-chromosome makes it an important locus to test the representativeness of a certain sample even in the genomic era, especially in poorly investigated areas like Africa.
- ArticleYang X, Huang G, An C, Chen X, Shen J, Yin J, Song P, Xu Z, Li Y.Sci Total Environ. 2021 Jan 01;750:141510.The groundwater with high arsenic concentration is widespread, especially in many remote areas of developing countries. Arsenic existing in drinking water sources has a high risk to human health. In this study, an innovative effort to remove As(V) from water using ceramic filters functionalized with CeO2 nanocomposites (CF-CeO2) was investigated. Considering removal efficiency and flow rate, the suitable coating amount of CeO2 was determined for the production of CF-CeO2. Based on the factorial analysis, influent arsenic concentration and pH were found to be significant factors in As(V) removal. Furthermore, CF-CeO2 exhibited a good removal capability over a wide pH range and was insensitive to the change of background electrolyte concentration. In the treatment of natural water, the existence of medium and low turbidity levels facilitated As(V) removing, while the high turbidity level exhibited the opposite effect. Based on macroscopic experiments and microscopic characterizations, it was revealed that the As(V) removal mechanism by the CF-CeO2 mainly included ion-exchange and electrostatic attraction. The findings in this study provided convincing evidence for the use of CF-CeO2 as a high-efficiency, low-cost, and safe approach for water purification in the remote areas of developing countries.
- Bookedited by Itai Ivtzan.Summary: "The rapid growth of mindfulness in the Western world has given rise to an unprecedented wave of creative mindfulness programmes, offering tailor-made mindfulness practices for school teachers, students, parents, nurses, yoga teachers, athletes, pregnant women, therapists, care-takers, coaches, organisational leaders and lawyers. This book offers an in-depth engagement with these different programmes, emphasising not only the theory and research but also the practice. Exercises and activities are provided to enable the reader to first understand the programme and then experience its unique approach and benefits."--Provided by publisher. Handbook of Mindfulness-Based Programmes: Mindfulness Interventions from Education to Health and Therapy offers the first comprehensive guide to all prominent, evidence-based mindfulness programmes available in the West. The rapid growth of mindfulness in the Western world has given rise to an unprecedented wave of creative mindfulness programmes, offering tailor-made mindfulness practices for school teachers, students, parents, nurses, yoga teachers, athletes, pregnant women, therapists, care-takers, coaches, organisational leaders and lawyers. This book offers an in-depth engagement with these different programmes, emphasising not only the theory and research but also the practice. Exercises and activities are provided to enable the reader to first understand the programme and then experience its unique approach and benefits. Handbook of Mindfulness-Based Programmes will enrich your knowledge and experience of mindfulness practice, whether you are a practitioner, researcher or simply interested in the application of mindfulness.
Contents:
Handbook of mindfulness-based programmes: an introduction / Itai Ivtzan
Acceptance and commitment therapy / Jennifer E. Krafft, Grayson M. Butcher, Michael E. Levin, and Michael P. Twohig
Cultivating wise mind dialectical behavior therapy through mindfulness / Dawn M. Salgado, Andrew W. White, Daphna Peterson, and Linda A. Dimeff
Mindfulness-based stress reduction: theory, practice, and evidence base / Diane Reibel and Donald McCown
Mindfulness-based positive behavior support / Nirbhay N. Singh, Giulio E. Lancioni, Jeffrey Chan, Carrie L. McPherson, and Monica M. Jackman
Mindfulness-based mind fitness training (MMFT): mindfulness training for high-stress and trauma-sensitive contexts / Kelsey L. Larsen and Elizabeth A. Stanley
Mindfulness-based emotional balance: history of development, curriculum, and research / Margaret Cullen, Gonzalo Brito-Pons, and Robert W. Roeser
Mindfulness-based childbirth and parenting: preparing a new generation for birthing and beyond / Nancy Bardacke and Larissa G. Duncan
Coping with the stress of parenting: the mindful parenting program / Lisa-Marie Emerson and Susan Bögels
Mindfulness-based relationship enhancement for couples / Nathan Bohy and James W. Carson
Mindful Mamas: mindfulness-based yoga for depressed women entering motherhood / Laurel M. Hicks, Barbara Brookens-Harvey, and Maria Muzik
A ceremony of losses: mindfulness for elders and caregivers / Lucia McBee and Antonella Buranello
Promoting healing through mindful medical practice / Patricia Lynn Dobkin
Mindfulness-based cancer recovery: an adaption of MBSR for people with cancer and their caregivers / Linda E. Carlson, Erin Zelinski, Kirsti Toivonen, and Michelle Flynn
Mindful sport performance enhancement (MSPE) / Keith A. Kaufman, Carol R. Glass, and Timothy R. Pineau
Mindfulness-based eating awareness training (MB-EAT) / Jean L. Kristeller
Mindfulness-based therapy for insomnia / Jason C. Ong and Rachel Manber
Cultivating awareness and resilience in education: the CARE for teachers program / Patricia A. Jennings, Anthony A. Demauro, and Polina Mischenko
"Wellness works in schools": the practice and research of a mindfulness program in urban middle schools / Cheryl T. Desmond, Wynne Kinder, Laurie B. Hanich, and Obioram C-B Chukwu
Mindfulness for adolescents: a review of the learning to BREATHE program / Jennifer L. Frank, Kimbery M. Kohler, Lamiya Khan, and Patricia C. Broderick
Audio-guided mindful-based social emotional learning (MBSEL) training in school classrooms: the inner explorer program / Jutta Tobias Mortlock
Still quiet place: sharing mindfulness with children and adolescents / Amy Saltzman
Mindfulness-based cognitive therapy for children / Jennifer Lee and Randye J. Semple
Mindful leadership / Jutta Tobias Mortlock and Jennifer Robinson
Mindfulness practice and the law: jurisight and the skillful means to greet the legal profession / Scott Rogers and Sarah Stuart
Mindfulness-oriented recovery enhancement: a review of its theoretical underpinnings, clinical application, and biobehavioral mechanisms / Eric L. Garland, Anne K. Baker, Michael R. Riquino, and Sarah E. Priddy
Mindfulness-based relapse prevention for addictive behaviors / Vanessa Somohano, Taylor Shank, and Sarah Bowen
Mindful self-compassion (MSC) / Christopher Germer and Kristin Neff
Mindfulness-based compassionate living (MBCL): a deepening programme for those with basic mindfulness skills / Erik Van Den Brink and Frits Koster
Mindfulness-based strengths practice (MBSP) / Roger Bretherton and Ryan M. Niemiec
Mindfulness-based flourishing program (positive mindfulness program) / Tarli Young and Itai Ivtzan.Digital Access TandFonline 2019 - ArticleAli Shah A, Shaker ASA, Jabbar S, Abbas Q, Al-Balawi TS, Celebi ME.Sci Rep. 2023 12 14;13(1):22251.When the mutation affects the melanocytes of the body, a condition called melanoma results which is one of the deadliest skin cancers. Early detection of cutaneous melanoma is vital for raising the chances of survival. Melanoma can be due to inherited defective genes or due to environmental factors such as excessive sun exposure. The accuracy of the state-of-the-art computer-aided diagnosis systems is unsatisfactory. Moreover, the major drawback of medical imaging is the shortage of labeled data. Generalized classifiers are required to diagnose melanoma to avoid overfitting the dataset. To address these issues, blending ensemble-based deep learning (BEDLM-CMS) model is proposed to detect mutation of cutaneous melanoma by integrating long short-term memory (LSTM), Bi-directional LSTM (BLSTM) and gated recurrent unit (GRU) architectures. The dataset used in the proposed study contains 2608 human samples and 6778 mutations in total along with 75 types of genes. The most prominent genes that function as biomarkers for early diagnosis and prognosis are utilized. Multiple extraction techniques are used in this study to extract the most-prominent features. Afterwards, we applied different DL models optimized through grid search technique to diagnose melanoma. The validity of the results is confirmed using several techniques, including tenfold cross validation (10-FCVT), independent set (IST), and self-consistency (SCT). For validation of the results multiple metrics are used which include accuracy, specificity, sensitivity, and Matthews's correlation coefficient. BEDLM gives the highest accuracy of 97% in the independent set test whereas in self-consistency test and tenfold cross validation test it gives 94% and 93% accuracy, respectively. Accuracy of in self-consistency test, independent set test, and tenfold cross validation test is LSTM (96%, 94%, 92%), GRU (93%, 94%, 91%), and BLSTM (99%, 98%, 93%), respectively. The findings demonstrate that the proposed BEDLM-CMS can be used effectively applied for early diagnosis and treatment efficacy evaluation of cutaneous melanoma.
- ArticleBorowczak J, Szczerbowski K, Maniewski M, Zdrenka M, Słupski P, Andrusewicz H, Łysik-Miśkurka J, Rutkiewicz P, Bodnar M, Szylberg Ł.Clin Transl Oncol. 2023 Mar;25(3):830-840.PURPOSE: The mutation of p53 is considered a pivotal step in bladder cancer pathogenesis. Recently, distinct interactions between p53 and CDK9, a transcription regulator, have been described. In this work, we explored the prognostic role of p53 expression and evaluated its associations with CDK9 in urothelial carcinoma.
MATERIALS AND METHODS: The research group consisted of 67 bladder cancer samples and 32 normal urothelial mucosa samples. All specimens were analyzed using ImageJ and the IHC profiler plugin. To validate the results, 406 cases from The Cancer Genome Atlas database were analyzed.
RESULTS: P53 and CDK9 are overexpressed in urothelial cancer tissues when compared to normal urothelial tissues (p < 0.05). High p53 expression was observed in metastatic tumors and tumors with high CDK9 expression (p < 0,05). High p53 expression was predictive for shorter survival in patients with non-muscle-invasive bladder cancer (HR = 0.107 [0.012-0.96]; p = 0.046) but did not correlate with prognosis in the muscle-invasive group. In high CDK9 cancers, high p53 expression correlated with the occurrence of high-grade and muscle-invasive tumors (p < 0.05).
CONCLUSION: High expression of p53 correlates with unfavorable clinical features of bladder cancer. CDK9 is associated with the expression of p53, possibly through interactions with p53 inhibitors. Since the blockade of CDK9 in other malignancies reactivates wild-p53 activity, confirming the crosstalk between p53 and CDK9 in bladder cancer may be another step to explain the mechanism of tumor progression in its early stages.