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- ArticleNaumova AK, Fayer S, Leung J, Boateng KA, Camerini-Otero RD, Taketo T.PLoS One. 2013;8(9):e75970.Failure of homologous synapsis during meiotic prophase triggers transcriptional repression. Asynapsis of the X and Y chromosomes and their consequent silencing is essential for spermatogenesis. However, asynapsis of portions of autosomes in heterozygous translocation carriers may be detrimental for meiotic progression. In fact, a wide range of phenotypic outcomes from meiotic arrest to normal spermatogenesis have been described and the causes of such a variation remain elusive. To better understand the consequences of asynapsis in male carriers of Robertsonian translocations, we focused on the dynamics of recruitment of markers of asynapsis and meiotic silencing at unsynapsed autosomal trivalents in the spermatocytes of Robertsonian translocation carrier mice. Here we report that the enrichment of breast cancer 1 (BRCA1) and histone γH2AX at unsynapsed trivalents declines during the pachytene stage of meiosis and differs from that observed in the sex body. Furthermore, histone variant H3.3S31, which associates with the sex chromosomes in metaphase I/anaphase I spermatocytes, localizes to autosomes in 12% and 31% of nuclei from carriers of one and three translocations, respectively. These data suggest that the proportion of spermatocytes with markers of meiotic silencing of unsynapsed chromatin (MSUC) at trivalents depends on both, the stage of meiosis and the number of translocations. This may explain some of the variability in phenotypic outcomes associated with Robertsonian translocations. In addition our data suggest that the dynamics of response to asynapsis in Robertsonian translocations differs from the response to sex chromosomal asynapsis in the male germ line.
- Bookedited by Şebnem Susam-Saraeva and Eva Spišiaková.Summary: "The Routledge Handbook of Translation and Health provides a bridge between translation studies and the burgeoning field of health humanities, which seeks novel ways of understanding health and illness. As discourses around health and illness are dependent on languages for their transmission, impact, spread, acceptance and rejection in local settings, translation studies offers a wealth of data, theoretical approaches and methods for studying health and illness globally. Translation and health intersect in a multitude of settings, historical moments, genres, media and users. This volume brings together topics ranging from interpreting in healthcare settings to translation within medical sciences, from historical and contemporary travels of medicine through translation to areas such as global epidemics, disaster situations, interpreting for children, mental health, women's health, disability, maternal health, queer feminisms and sexual health, and nutrition. Contributors come from a wide range of disciplines, not only from various branches of translation and interpreting studies, but also from disciplines such as psychotherapy, informatics, health communication, interdisciplinary health science and classical Islamic studies. Divided into four sections and each contribution written by leading international authorities, this timely handbook is an indispensable resource for all students and researchers of translation and health within translation and interpreting studies, as well as medical and health humanities"-- Provided by publisher
Contents:
Introduction. Beyond translation and medicine : initiating exchanges between translation studies and health humanities / Şebnem Susam-Saraeva and Eva Spišiaková
Medical translations from Greek Into Arabic and Hebrew / Elaine van Dalen
Translations of Western medical texts in East Asia in the second half of the 19th and early 20th centuries / Ji-Hae Kang
Dissemination of academic medical research through translation throughout history and in contemporary world / Carmen Quijada Diez
Medical terminology and discourse / Joost Buysschaert
Quality, accessibility and readability in medical translation / Wioleta Karwacka
Inter- and intralingual translation of medical information : the importance of comprehensibility / Matilde Nisbeth Brøgger and Karen Korning Zethsen
Machine translation in healthcare / Barry Haddow, Alexandra Birch and Kenneth Heafield
Medical humanities and translation / Vicent Montalt
Knowledge translation / John Ødemark, Gina Fraas Henrichsen and Eivind Engebretsen
Community/liaison interpreting in healthcare settings / Bruce Downing
Child language brokering in healthcare settings / Rachele Antonini and Ira Torresi
Healthcare interpreting ethics : a critical review / Robyn Dean
Remote (telephone) interpreting in healthcare settings / Raquel Lázaro Gutiérrez
Reducing health disparities in the deaf community : the impact of interpreters and the rise of deaf healthcare professionals / Christopher J. Moreland and Laurie Swabey
Translation and interpreting in disaster situations / Patrick Cadwell
Translating global epidemics : the case of Ebola / Tony Joakim Sandset
Interpreter-mediated communication with children in health care settings / Anne Birgitta Nilsen
Disability in translation / Eva Spišiaková
Queer feminisms and the translation of sexual health / Michela Baldo
Translation and women's health / Nesrine Bessaïh
Translation in maternal and neonatal health / Şebnem Susam-Saraeva and Luciana Carvalho Fonseca
Dialogue interpreting in mental healthcare : supportive interference / Hanneke Bot
Nutrition and translation / Renée Desjardins.