Bookedited by Raj Bawa, János Szebeni, Thomas J. Webster, Gerald F. Audette.
Summary: "The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics"--Publisher's description.
Contents:
Current immune aspects of biologics and nanodrugs: an overview / Raj Bawa
Immunological issues with medicines of nano size: the price of dimension paradox / János Szebeni and Raj Bawa
Immunotherapy and vaccines / Johanna Poecheim and Gerrit Borchard
Site-specific antibody conjugation for ADC and beyond / Qun Zhou
Current understanding of interactions between nanoparticles and the immune system / Marina A. Dobrovolskaia, Michael Shurinand, Anna A. Shvedova
Auto-antibodies as biomarkers for disease diagnosis / Angelika Lueking, Heike Göhlerand, Peter Schulz-Knappe
The acceleated blood clearance phenomenon of PEGylated nanocarriers / Amr S. Abu Lila and Tatsuhiro Ishida
Anti-PEG immunity against PEGylated therapeutics / Amr S. Abu Lila and Tatsuhiro Ishida
Complement activation: challenges to nanomedicine development / Dennis E. Hourcade, Christine T. N. Phamand, Gregory M. Lanza
Intravenous immunoglobulin at the borderline of nanomedicines and biologicals: antithrombogenic effect via complement attenuation / Milan Basta
Lessons learned from the porcine CARPA Model: constant and variable responses to different nanomedicines and administration protocols / Rudolf Urbanics, Péter Bedőcs and János Szebeni
Blood cell changes in complement activation-related pseudoallergy: intertwining of cellular and humoral interactions / Zsófia Patkó and János Szebeni
Rodent models of complement activation-related pseudoallergy: inducers, symptoms, inhibitors and reaction mechanisms / László Dézsi, László Rosivall, Péter Hamar, János Szebeni and Gábor Szénási
Immune reactions in the delivery of RNA interference-based therapeutics: mechanisms and opportunities / Kaushik Thanki, Emily Falkenberg, Monique Gangloff and Camilla Foged
Lipid nanoparticle induced immunomodulatory effects of siRNA / Ranjita Shegokar and Prabhat Mishra
Nanovaccines against intracellular pathogens using Coxiella burneti as a model organism / Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette and James E. Samuel
Immunogenicity assessment for therapeutic protein products / U.S. Food and Drug Administration, Center for Drug Evaluation and Research
Assay development and validation for immunogenicity testing of therapeutic protein products / U.S. Food and Drug Administration, Center for Drug Evaluation and Research
/ The "sentinel": a conceptual nanomedical strategy for the enhancement of the human immune system / Frank J. Boehm and Angelika Domschke
Immunotherapy for gliomas and other intracranial malignancies / Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro and Andrea Soddu
Engineering nanoparticles to overcome barriers to immunotherapy / Randall Toyand, Krishnendu Roy
Metal-based nanoparticles and theimmune system: activation, inflammation, and potential applications / Yueh-Hsia Luo, Louis W. Chang and Pinpin Lin
Silica nanoparticles effects on hemostasis / Volodymyr Gryshchuk, Volodymyr Chernyshenko, Tamara Chernyshenko, Olha Hornytska, Natalya Galaganand, Tetyana Platonova
Valproate-induced rodent model of autism spectrum disorder: immunogenic effects and role of microglia / Prabha S. Awale, James C. K. Lai, Srinath Pashikanthiand Alok Bhushan
Accelerated blood clearance phenomenon and complement activation-related pseudoallergy: two sides of the same coin / Amr S. Abu Lila, Janos Szebeniand Tatsuhiro Ishida
Current and rising concepts in immunotherapy: biopharmaceuticals versus nanomedicines / Matthias Bartneck
Characterization of the interaction between nanomedicines and biological components: in vitro evaluation / Cristina Fornaguera
Unwanted immunogenicity: from risk assessment to risk management / Cheryl Scott
Emerging therapeutic potential of nanoparticles in pancreatic cancer: a systematic review of clinical trials / Minnie Au, MBBS, Theophilus I. Emeto, Jacinta Power, Venkat N. Vangaveti and, Hock C. Lai
SGT-53: a novel nanomedicine capable of augmenting cancer immunotherapy / Joe B. Harford, Sang-Soo Kim, Kathleen F. Pirollo, Antonina Raitand, Esther H. Chang.