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  • Book
    edited by Raj Bawa, János Szebeni, Thomas J. Webster, Gerald F. Audette.
    Summary: "The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics"--Publisher's description.

    Current immune aspects of biologics and nanodrugs: an overview / Raj Bawa
    Immunological issues with medicines of nano size: the price of dimension paradox / János Szebeni and Raj Bawa
    Immunotherapy and vaccines / Johanna Poecheim and Gerrit Borchard
    Site-specific antibody conjugation for ADC and beyond / Qun Zhou
    Current understanding of interactions between nanoparticles and the immune system / Marina A. Dobrovolskaia, Michael Shurinand, Anna A. Shvedova
    Auto-antibodies as biomarkers for disease diagnosis / Angelika Lueking, Heike Göhlerand, Peter Schulz-Knappe
    The acceleated blood clearance phenomenon of PEGylated nanocarriers / Amr S. Abu Lila and Tatsuhiro Ishida
    Anti-PEG immunity against PEGylated therapeutics / Amr S. Abu Lila and Tatsuhiro Ishida
    Complement activation: challenges to nanomedicine development / Dennis E. Hourcade, Christine T. N. Phamand, Gregory M. Lanza
    Intravenous immunoglobulin at the borderline of nanomedicines and biologicals: antithrombogenic effect via complement attenuation / Milan Basta
    Lessons learned from the porcine CARPA Model: constant and variable responses to different nanomedicines and administration protocols / Rudolf Urbanics, Péter Bedőcs and János Szebeni
    Blood cell changes in complement activation-related pseudoallergy: intertwining of cellular and humoral interactions / Zsófia Patkó and János Szebeni
    Rodent models of complement activation-related pseudoallergy: inducers, symptoms, inhibitors and reaction mechanisms / László Dézsi, László Rosivall, Péter Hamar, János Szebeni and Gábor Szénási
    Immune reactions in the delivery of RNA interference-based therapeutics: mechanisms and opportunities / Kaushik Thanki, Emily Falkenberg, Monique Gangloff and Camilla Foged
    Lipid nanoparticle induced immunomodulatory effects of siRNA / Ranjita Shegokar and Prabhat Mishra
    Nanovaccines against intracellular pathogens using Coxiella burneti as a model organism / Erin J. van Schaik, Anthony E. Gregory, Gerald F. Audette and James E. Samuel
    Immunogenicity assessment for therapeutic protein products / U.S. Food and Drug Administration, Center for Drug Evaluation and Research
    Assay development and validation for immunogenicity testing of therapeutic protein products / U.S. Food and Drug Administration, Center for Drug Evaluation and Research
    / The "sentinel": a conceptual nanomedical strategy for the enhancement of the human immune system / Frank J. Boehm and Angelika Domschke
    Immunotherapy for gliomas and other intracranial malignancies / Mario Ganau, Gianfranco K. I. Ligarotti, Salvatore Chibbaro and Andrea Soddu
    Engineering nanoparticles to overcome barriers to immunotherapy / Randall Toyand, Krishnendu Roy
    Metal-based nanoparticles and theimmune system: activation, inflammation, and potential applications / Yueh-Hsia Luo, Louis W. Chang and Pinpin Lin
    Silica nanoparticles effects on hemostasis / Volodymyr Gryshchuk, Volodymyr Chernyshenko, Tamara Chernyshenko, Olha Hornytska, Natalya Galaganand, Tetyana Platonova
    Valproate-induced rodent model of autism spectrum disorder: immunogenic effects and role of microglia / Prabha S. Awale, James C. K. Lai, Srinath Pashikanthiand Alok Bhushan
    Accelerated blood clearance phenomenon and complement activation-related pseudoallergy: two sides of the same coin / Amr S. Abu Lila, Janos Szebeniand Tatsuhiro Ishida
    Current and rising concepts in immunotherapy: biopharmaceuticals versus nanomedicines / Matthias Bartneck
    Characterization of the interaction between nanomedicines and biological components: in vitro evaluation / Cristina Fornaguera
    Unwanted immunogenicity: from risk assessment to risk management / Cheryl Scott
    Emerging therapeutic potential of nanoparticles in pancreatic cancer: a systematic review of clinical trials / Minnie Au, MBBS, Theophilus I. Emeto, Jacinta Power, Venkat N. Vangaveti and, Hock C. Lai
    SGT-53: a novel nanomedicine capable of augmenting cancer immunotherapy / Joe B. Harford, Sang-Soo Kim, Kathleen F. Pirollo, Antonina Raitand, Esther H. Chang.
    Digital Access TandFonline 2019