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  • Article
    Ding Y, Yan JL, Fang AN, Zhou WF, Huang L.
    Oncotarget. 2017 Sep 12;8(39):66402-66413.
    The diagnostic value and suitability of circulating miRNAs for the detection of hepatocellular carcinoma have been inconsistent in the literature. A meta-analysis is used to systematically evaluate the diagnostic value of circulating miRNAs. Eligible studies were selected and the heterogeneity was assessed by subgroup analysis, meta-regression, and publication bias. After strictly and comprehensive screening, the source methods, internal reference and the cut-off values of the included miRNAs were first listed. Circulating miRNAs demonstrated a relatively good diagnostic value in hepatocellular carcinoma, In the subgroup analysis, diagnosis odds ratio showed a higher accuracy with multiple miRNAs than with a single miRNA as well as with serum types than plasma types. In addition, although miRNAs have many expression patterns, the high frequency expression miRNAs (miR-21, miR-199 and miR-122) might be more specific for the diagnosis of hepatocellular carcinoma.The sources of heterogeneity might be related to the number of miRNAs and the specimen types in meta-regression. Furthermore, it's surprised that the pooled studies were first demonstrated publication bias (P < 0.05). In conclusion, multiple miRNAs in serum have a better diagnostic value, and the publication bias was stable. To validate the potential applicability of miRNAs in the diagnosis of hepatocellular carcinoma, more rigorous studies are needed to confirm these conclusions.
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  • Article
    O'Mahony AM, Ogier J, Darcy R, Cryan JF, O'Driscoll CM.
    PLoS One. 2013;8(6):e66413.
    Optimising non-viral vectors for neuronal siRNA delivery presents a significant challenge. Here, we investigate a co-formulation, consisting of two amphiphilic cyclodextrins (CDs), one cationic and the other PEGylated, which were blended together for siRNA delivery to a neuronal cell culture model. Co-formulated CD-siRNA complexes were characterised in terms of size, charge and morphology. Stability in salt and serum was also examined. Uptake was determined by flow cytometry and toxicity was measured by MTT assay. Knockdown of a luciferase reporter gene was used as a measure of gene silencing efficiency. Incorporation of a PEGylated CD in the formulation had significant effects on the physical and biological properties of CD.siRNA complexes. Co-formulated complexes exhibited a lower surface charge and greater stability in a high salt environment. However, the inclusion of the PEGylated CD also dramatically reduced gene silencing efficiency due to its effects on neuronal uptake. The co-formulation strategy for cationic and PEGylated CDs improved the stability of the CD.siRNA delivery systems, although knockdown efficiency was impaired. Future work will focus on the addition of targeting ligands to the co-formulated complexes to restore transfection capabilities.
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  • Article
    Zhu T, Wang L, Ding X, Wen Z, He L, Chen J, Yang Y, Liu Z, Chen J, Zhang M.
    Environ Sci Pollut Res Int. 2022 Sep;29(44):66413-66421.
    Turions production is the dominant means of propagation in Potamogeton crispus L. To understand how parental population and their living environmental factors influence the turions production of P. crispus L., a field research was conducted in Nansi Lake in Yellow River Flood Plain and southwestern Shandong Province, China. This study showed that P. crispus biomass and asexual turions showed an almost uniform spatial distribution pattern. Water depth, attenuation coefficient of light, sediment water content, sediment organic matter content, and pH were significantly related to P. crispus biomass, turions weight, and turions number. Single turion weight was determined only by P. crispus biomass, while turions number was simultaneously determined by P. crispus biomass and sediment water content. Turions weight mainly depended on turions number rather than single turion weight, and maternal biomass and sediment water content determined turions weight by affected turions number rather than single turion weight.
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  • Article
    Hughto J, Horowitz CJ, Schneider AS, Medin Z, Cumming A, Berry DK.
    Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Dec;86(6 Pt 2):066413.
    The neutron-rich isotope ²²Ne may be a significant impurity in carbon and oxygen white dwarfs and could impact how the stars freeze. We perform molecular dynamics simulations to determine the influence of ²²Ne in carbon-oxygen-neon systems on liquid-solid phase equilibria. Both liquid and solid phases are present simultaneously in our simulation volumes. We identify liquid, solid, and interface regions in our simulations using a bond angle metric. In general we find good agreement for the composition of liquid and solid phases between our MD simulations and the semianalytic model of Medin and Cumming. The trace presence of a third component, neon, does not appear to strongly impact the chemical separation found previously for two-component carbon and oxygen systems. This suggests that small amounts of ²²Ne may not qualitatively change how the material in white dwarf stars freezes. However, we do find systematically lower melting temperatures (higher Γ) in our MD simulations compared to the semianalytic model. This difference seems to grow with impurity parameter Q_{imp} and suggests a problem with simple corrections to the linear mixing rule for the free energy of multicomponent solid mixtures that is used in the semianalytic model.
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  • Article
    Solodov AA, Malkin VM, Fisch NJ.
    Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jun;69(6 Pt 2):066413.
    Extremely large laser power might be obtained by compressing laser pulses through backward Raman amplification (BRA) in plasmas. Premature Raman backscattering of a laser pump by plasma noise might be suppressed by an appropriate detuning of the Raman resonance, even as the desired amplification of the seed persists with a high efficiency. In this paper we analyze side scattering of laser pumps by plasma noise in backward Raman amplifiers. Though its growth rate is smaller than that of backscattering, the side scattering can nevertheless be dangerous, because of a longer path of side-scattered pulses in plasmas and because of an angular dependence of the Raman resonance detuning. We show that side scattering of laser pumps by plasma noise in BRA might be suppressed to a tolerable level at all angles by an appropriate combination of two detuning mechanisms associated with plasma density gradient and pump chirp.
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  • Article
    Adams ML, Lee RW, Scott HA, Chung HK, Klein L.
    Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Dec;66(6 Pt 2):066413.
    Both the theoretical basis and the computational approach for extending the capabilities of an established spectral line broadening code are presented. By following standard line broadening theory, the effects of an external magnetic field are incorporated into the plasma average and atomic Hamiltonian. An external magnetic field introduces a preferential axis that destroys the symmetry of the quasistatic electric ion microfield. An external magnetic field also modifies the angular properties of the atomic Hamiltonian-atomic energy levels are perturbed and the spectral emission line is polarized. These extensions have been incorporated in an atomic line shape code for complex atoms and applied to several problems of importance to the understanding of tokamak edge plasmas. Applications fall into two broad categories: (1) determination of local plasma properties, such as the magnetic field strength, from distinct line shape features; and (2) consideration of global plasma phenomenon, such as radiation transport. Observable features of the Zeeman effect make H(alpha) a good line for diagnosing the magnetic field. H(beta) does not make a good electron density diagnostic since the Zeeman effect is comparable to the Stark effect for a majority of tokamak edge plasma conditions. For optically thick lines, the details of the spectral line shapes are shown to significantly influence the transport of radiation throughout the system.
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  • Article
    Choueiri EY.
    Phys Rev E Stat Nonlin Soft Matter Phys. 2001 Dec;64(6 Pt 2):066413.
    The microinstability of a cross-field current-carrying plasma in which the electron collisions are important on the time scale of the oscillations and can be modeled with a Bhatnagar-Gross-Krook operator is studied using linearized kinetic theory under conditions of finite electron beta. The finiteness of beta allows for coupling between electrostatic and electromagnetic modes and necessitates dealing with the entire dispersion tensor. Fundamental features of the resulting instability are identified and contrasted with those found in previous studies of the lower hybrid current-driven instability in which either collisions or finite-beta effects were neglected. As beta increases, collisions play a more important role in destabilization, alter the character and extent of electromagnetic coupling, shift the instability to more perpendicular modes, and lead to a recapturing of some of the fluidlike properties the modes have in the electrostatic limit in contrast with their highly kinetic character in the collisionless limit.
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  • Book
    [edited by] Carla Jackie Sampson, Bruce J. Fried.
    Summary: "The third edition of Fundamentals of Human Resources in Healthcare is updated to include the contemporary issues in healthcare HR made more urgent by the Great Resignation and resulting shockwaves to the employer-employee relationship. This edition includes a new chapter on Employee Well Being and a revamped chapters on Organizational and Employee Development, Diversity, Inclusion, and Belonging, and Aligning Quality Improvement and Implementation Science with HR Practices"-- Provided by publisher.

    Contents:
    Strategic Human Resources Management / Carla Jackie Sampson
    The Healthcare Professional / Patrick D. Shay and Dolores G. Clement
    The Legal and Ethical Environment / Drake Maynard
    Job Analysis and Job Design / Sean N. Newman and Paige N. Ocker
    Recruitment, Selection, and Retention / Gabriela "Gabbi" J. Maris and Bruce J. Fried
    Organizational and Employee Development / Carla Jackie Sampson and Julene Campion
    Performance Management / Bruce J. Fried
    Compensation Practices, Planning, and Challenges / Bruce J. Fried, Brigid K. Grabert, and John Cashion
    Employee Benefits / Melissa G. McCraw and Dolores G. Clement
    Organized Labor / Carla Jackie Sampson, Bruce J. Fried, and Donna Malvey
    Diversity, Inclusion, and Belonging in the Workplace / Carla Jackie Sampson, Bruce J. Fried, and Jeffrey Simms
    Applying Quality Improvement and Implementation Science in Human Resources Practices / Hilary K. Hecht and Bruce J. Fried
    Employee Well-Being / Amanda Raffenaud and Tina Yeung.
    Digital Access R2Library [2023]