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  • Article
    Corsi MP, Darwiche HF, Nham F, Court T, Goitz H.
    Cureus. 2024 Mar;16(3):e56529.
    Cyclops lesions are characterized as fibroid nodules with granulation tissue that looks similar to a cyclops eye during arthroscopy. These are rare postoperative complications following anterior cruciate ligament reconstruction (ACLR), presenting typically within six months of their reconstruction. This case report presents a 21-year-old male, three years following hamstring autograft ACLR, with a symptomatic cyclops lesion. Contrary to the reported literature, this delayed presentation showed a painful flexion contracture of the knee and intraoperative findings consistent with a cyclops lesion. The treatment consisted of surgical debridement and notchplasty with subsequent posterior medial and lateral meniscal horn repairs. This case report presents a lesson to indicate that cyclops lesions can occur in a delayed setting following ACLR and to show a technique for successful surgical management of the lesion.
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  • Article
    Turlin E, Débarbouillé M, Augustyniak K, Gilles AM, Wandersman C.
    PLoS One. 2013;8(2):e56529.
    EfeUOB-like tripartite systems are widespread in bacteria and in many cases they are encoded by genes organized into iron-regulated operons. They consist of: EfeU, a protein similar to the yeast iron permease Ftrp1; EfeO, an extracytoplasmic protein of unknown function and EfeB, also an extracytoplasmic protein with heme peroxidase activity, belonging to the DyP family. Many bacterial EfeUOB systems have been implicated in iron uptake, but a prefential iron source remains undetermined. Nevertheless, in the case of Escherichia coli, the EfeUOB system has been shown to recognize heme and to allow extracytoplasmic heme iron extraction via a deferrochelation reaction. Given the high level of sequence conservations between EfeUOB orthologs, we hypothesized that heme might be the physiological iron substrate for the other orthologous systems. To test this hypothesis, we undertook characterization of the Staphylococcus aureus FepABC system. Results presented here indicate: i) that the S. aureus FepB protein binds both heme and PPIX with high affinity, like EfeB, the E. coli ortholog; ii) that it has low peroxidase activity, comparable to that of EfeB; iii) that both FepA and FepB drive heme iron utilization, and both are required for this activity and iv) that the E. coli FepA ortholog (EfeO) cannot replace FepA in FepB-driven iron release from heme indicating protein specificity in these activities. Our results show that the function in heme iron extraction is conserved in the two orthologous systems.
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  • Article
    Kafle P, Sanghavi R, Khasbaatar A, Punjani S, Davies DW, Diao Y.
    ACS Appl Mater Interfaces. 2021 Dec 01;13(47):56519-56529.
    Nanosizing has emerged as one of the most effective formulation strategies for enhancement of dissolution properties of active pharmaceutical ingredients (APIs). In addition to enhancing the specific area of the dissolving solids, nanosizing can also capture and stabilize the metastable form of the API, which can further enhance the solubility by drastic modulation of surface energies. Herein, we employ meniscus-guided coating to fabricate nanothin films of three APIs that show anticancer properties and are poorly soluble:10-HCPT, SN-38, and amonafide. By modulating the coating speed, we systematically deposited the APIs in films ranging from ∼200 nm thickness to extreme confinement of ∼10 nm (<10 molecular layers). In all three APIs, we observe a general order-to-disorder transition with semicrystalline (10-HCPT and amonafide) or amorphous (SN-38) form of API solids trapped in thin films when the thickness decreases below a critical value of ∼25-30 nm. The existence of a critical thickness highlights the importance of nanoconfinement in tuning molecular packing. In the case of 10-HCPT, we demonstrate that the disordered form of the API occurs largely due to lack of incorporation of water molecules in thinner films below the critical thickness, thereby disrupting the three-dimensional hydrogen-bonded network held by water molecules. We further developed a dissolution model that predicts variation of the intrinsic dissolution rate (IDR) with API film thickness, which also closely matched with experimental results. We achieved drastic improvement in the IDR of ∼240% in 10-HCPT by decreasing film thickness alone. Further leveraging the order-to-disorder transition led to 2570% modulation of the IDR for amonafide. Our work demonstrates, for the first time, opportunities to largely modulate API dissolution by precisely controlling the dimensionality of thin films.
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  • Article
    Ito M, Yamashita Y, Tsuneda Y, Mori T, Takeya J, Watanabe S, Ariga K.
    ACS Appl Mater Interfaces. 2020 Dec 16;12(50):56522-56529.
    The Langmuir-Blodgett (LB) and Langmuir-Schaefer techniques facilitate thermodynamic favorability at an air-water interface, at which nanoscale molecular aggregations can be manipulated by micrometer- or millimeter-scale mechanics. The customary use of an aqueous subphase has limitations in the available temperature and spread materials. We present a general strategy to replace the aqueous subphase with an inert, low-vapor-pressure liquid, ethylene glycol. As a representative spread material that requires high-temperature processes, a semicrystalline polymeric semiconductor was investigated. We successfully demonstrated that the polymeric semiconductor spreads homogeneously across the entire surface of ethylene glycol heated to 100 °C using an LB trough, and spontaneously forms multilayers. Comprehensive studies such as X-ray diffraction, optical spectroscopy, and charge transport measurements revealed that barrier compression of solid-state polymer thin films during a high-temperature LB process produced uniaxial alignment of the polymer main chain with an averaged dichroic ratio of about 8, by which the electron transport concomitantly became highly anisotropic. The LB method presented in this work could be used to deposit thin films under ultimate environments, e.g., below 0 °C or above 100 °C, minimizing the effects of the vapor pressure of the subphase.
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  • Book
    [edited by] Farhood Saremi ; associate editors, Dakshesh B. Patel, Damián Sánchez-Quintana, Hiro Kiyosue, Meng Law, R. Shane Tubbs.
    Summary: "The text is supported by high-quality cross-sectional images with correlative three-dimensional and color-coded CT and MR views. Up-to-date references are used to support the text. Many new topics in radiology and surgery have been gathered from the recent 10-year literature. Surgical and clinical applications in each anatomy topic are presented with relevant images. In order to make each topic understandable, difficult anatomical concepts are supported by sketches as well as cross-sectional and topographic cadaveric views provided by internationally known anatomists. Superb cadaveric views are provided by Professors Damián Sánchez-Quintana, R. Shane Tubbs, and the late Professor Albert L. Rhoton Jr. Images of high-resolution axial cadaveric cuts have been provided by the University of Auckland, New Zealand, thanks to efforts of Professor Ali Mirjalili." -- portion of preface by Farhood Saremi

    Contents:
    Imaging Anatomy
    Title
    Copyright
    Contents
    Preface
    Contributors
    1 Bones, Muscles, Tendons, Joints and Cartilage
    2 Upper Extremity Bones: Shoulder Girdle, Arm and Forearm
    3 Muscles of Shoulder Girdle, Arm and Forearm
    4 Upper Extremity Arteries
    5 Upper Extremity and Shoulder Venous System
    6 Brachial Plexus and Its Branches
    7 Lymphatic System of the Upper Extremity
    8 Lower Extremity Bones: Pelvis, Femur, Tibia, Fibula
    9 Lower Extremity Muscles: Pelvic Girdle, Thigh and Leg
    10 Accessory Muscles
    11 Lower Extremity Arteries; 12 Lower Extremity and Pelvic Venous System
    13 Lower Extremity Nerves
    14 Lymphatics of the Lower Extremities
    15 Anatomy of the Shoulder Joint
    16 Elbow Joint
    17 Wrist
    18 Hand
    19 Sacrum, Coccyx and Sacroiliac Joints
    20 Hip
    21 Knee
    22 Ankle
    23 Foot
    24 Temporomandibular Joint
    Index.
    Digital Access Thieme MedOne Education 2024