Live Chat
Today's Hours: 8:00am - 10:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Article
    Pandey AS, Bawiskar D, Wagh V.
    Cureus. 2024 Jan;16(1):e52754.
    The development of nanocosmetics nanotechnology has ushered in a new age in cosmetic research, completely changing the skincare scene. This abstract investigates the relationship between skincare and nanotechnology, particularly emphasizing the effects of nanocosmetics on skin health. Cosmetics, known as "nanocosmetics," use materials at the nanoscale, typically between 1 and 100 nanometers, to improve the effectiveness and delivery of active chemicals. Nanotechnology in cosmetics allows for the development of sophisticated delivery methods that provide enhanced stability and tailored distribution, including nanoemulsions and nanocapsules. This breakthrough overcomes the constraints of conventional formulations by enabling the entry of active ingredients into the skin's deeper layers. Studies investigating nanocosmetics and skin health were included. This encompassed in vitro studies, animal models, and clinical studies of various designs. Exclusion criteria included studies focusing solely on nanotechnology unrelated to skin health or nanocosmetics and review articles editorials, commentaries, and conference abstracts. Nanocosmetics is a groundbreaking development in skincare that provides creative answers to a range of skin issues. As the area develops, realizing the full potential of nanotechnology in fostering ideal skin health will need sustained research and adherence to safety regulations.
    Digital Access Access Options
  • Article
    Trejo-Becerril C, Pérez-Cárdenas E, Taja-Chayeb L, Anker P, Herrera-Goepfert R, Medina-Velázquez LA, Hidalgo-Miranda A, Pérez-Montiel D, Chávez-Blanco A, Cruz-Velázquez J, Díaz-Chávez J, Gaxiola M, Dueñas-González A.
    PLoS One. 2012;7(12):e52754.
    It is known that cancer progresses by vertical gene transfer, but this paradigm ignores that DNA circulates in higher organisms and that it is biologically active upon its uptake by recipient cells. Here we confirm previous observations on the ability of cell-free DNA to induce in vitro cell transformation and tumorigenesis by treating NIH3T3 recipient murine cells with serum of colon cancer patients and supernatant of SW480 human cancer cells. Cell transformation and tumorigenesis of recipient cells did not occur if serum and supernatants were depleted of DNA. It is also demonstrated that horizontal cancer progression mediated by circulating DNA occurs via its uptake by recipient cells in an in vivo model where immunocompetent rats subjected to colon carcinogenesis with 1,2-dimethylhydrazine had increased rate of colonic tumors when injected in the dorsum with human SW480 colon carcinoma cells as a source of circulating oncogenic DNA, which could be offset by treating these animals with DNAse I and proteases. Though the contribution of biologically active molecules other than DNA for this phenomenon to occur cannot be ruled out, our results support the fact that cancer cells emit into the circulation biologically active DNA to foster tumor progression. Further exploration of the horizontal tumor progression phenomenon mediated by circulating DNA is clearly needed to determine whether its manipulation could have a role in cancer therapy.
    Digital Access Access Options
  • Article
    Ham SL, Atefi E, Fyffe D, Tavana H.
    J Vis Exp. 2015 Apr 23(98):e52754.
    Cancer cell spheroids present a relevant in vitro model of avascular tumors for anti-cancer drug testing applications. A detailed protocol for producing both mono-culture and co-culture spheroids in a high throughput 96-well plate format is described in this work. This approach utilizes an aqueous two-phase system to confine cells into a drop of the denser aqueous phase immersed within the second aqueous phase. The drop rests on the well surface and keeps cells in close proximity to form a single spheroid. This technology has been adapted to a robotic liquid handler to produce size-controlled spheroids and expedite the process of spheroid production for compound screening applications. Spheroids treated with a clinically-used drug show reduced cell viability with increase in the drug dose. The use of a standard micro-well plate for spheroid generation makes it straightforward to analyze viability of cancer cells of drug-treated spheroids with a micro-plate reader. This technology is straightforward to implement both robotically and with other liquid handling tools such as manual pipettes.
    Digital Access Access Options
  • Article
    Yang S, Li Q, Li C, Cao T, Wang T, Fan F, Zhang X, Fu Y.
    ACS Appl Mater Interfaces. 2021 Nov 10;13(44):52754-52764.
    The implementation of the p-type metal oxide semiconductor (MOS) in modern sensing systems requires a strategy to effectively enhance its inherent low response. However, for p-type MOS sensors, conventional methods such as catalyst nanoparticle (NP) decoration and grain size regulation do not work as effectively as they do for n-type MOS sensors, which is basically due to the fact that the p-type MOS adopts an unfavorable parallel conduction model. Herein, taking Au@PdO as an example, we demonstrate that the conduction model of the p-type MOS can be manipulated into the series conduction model by inserting a high-conductive metallic core into less-conductive p-type MOS NPs. This unique series conduction model makes the sensor response of Au@PdO nanoparticle arrays (NAs) very sensitive to the catalyst NP decoration as well as the change of structural parameters. For example, Au@PdO NAs demonstrate an ∼9000 times increase in sensor response when decorated with Pd NPs, whereas there is only ∼100 times increase for PdO NAs. This greatly improved response value outperforms all previously reported PdO-based (and most other p-type semiconductor-based) H2 sensors, which helps the obtained sensor to achieve an ultralow detection limit of ∼0.1 ppm at room temperature. Additionally, Au@PdO NAs inherit the high surface reactivity and gas adsorption property of p-type PdO. As a result, the as-prepared sensor exhibits high humidity-resistive property and excellent selectivity. This work provides a new strategy to significantly enhance the sensing performance of p-type gas sensors by manipulating their conduction model.
    Digital Access Access Options
  • Article
    Becker KP, Hannun YA.
    J Biol Chem. 2003 Dec 26;278(52):52747-54.
    In addition to the classical role of protein kinase C (PKC) as a mediator of transmembrane signals initiated at the plasma membrane, there is also significant evidence to suggest that a more sustained PKC activity is necessary for a variety of long term cellular responses. To date, the subcellular localization of PKC during sustained activation has not been extensively studied. We report here that long term activation of PKC (1 h) leads to the selective translocation of classical PKC isoenzymes, alpha and betaII, to a juxtanuclear compartment. Juxtanuclear translocation of PKC required an intact C1 and C2 domain, and occurred in a microtubule-dependent manner. This juxtanuclear compartment was localized close to the Golgi complex but displayed no overlap with Golgi markers, and was resistant to dispersal with Golgi disrupting agents, brefeldin A and nocodazole. Further characterization revealed that PKCalpha and betaII translocated to a compartment that colocalized with the small GTPase, rab11, which is a marker for the subset of recycling endosomes concentrated around the microtubule-organizing center/centrosome. Analysis of the functional consequence of cPKC translocation on membrane recycling demonstrated a cPKC-dependent sequestration of transferrin, a marker of membrane recycling, in the cPKC compartment. These results identify a novel site for cPKC translocation and define a novel function for the sustained activation of PKCalpha and betaII in regulation of recycling components.
    Digital Access Access Options
  • Book
    Thoru Yamada, Elizabeth Meng.
    Contents:
    Section 1: Evoked potentials. Principles of evoked potentials ; Visual evoked potentials ; Brainstem auditory evoked potentials and auditory evoked potentials ; Somastosensory evoked potentials
    Section 2: Intraoperative neurophysiologic monitoring. The technologist's role in neurophysiologic intraoperative monitoring ; Brain function monitoring for carotid endarterectomy and aortic arch surgery ; Spinal cord monitoring ; Intraoperative monitoring of the brainstem and cranial nerve function
    Section 3: Long-term EEG monitoring. Diagnostic video-EEG monitoring for epilepsy and spells: indications, application, and interpretation ; Invasive video EEG monitoring in epilepsy surgery candidates: indications, technique, and interpretation ; Long-term bedside EEG monitoring for acutely ill patients (LTM/ccEEG)
    Section 4: Sleep studies. Technology of polysomnography ; Sleep physiology and pathology ; Sleep apnea and related conditions ; Evaluating narcolepsy and related conditions ; Parasomnias ; Electrophysiological measurement and rules for sleep-related movement disorders
    Section 5: Nerve conduction studies. Nerve conduction and electromyography studies.
    Digital Access LWW Health Library 2022