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- ArticleCoutinho A, Forni L, Melchers F, Watanabe T.Eur J Immunol. 1977 May;7(5):325-8.Splenic B cells C57BL/10ScCr mice fail to respond to the mitogenic principle of lipopolysaccharide (LPS), and do not express a serologically defined "LPS receptor". In contrast, polyclonal B cell responses to both purified protein derivative of tuberculin and lipoprotein are conserved.