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  Accroissement de l'oxygène disponible du cortex cérébral par administration d'inhibiteurs de l'anhydrase carbonique [Increase in the oxygen available to the cerebral cortex after the administration of carbonic anhydrase inhibitors].

  Boulu R, Plotkine M, Guéniau C, Rossignol P.

  C R Acad Hebd Seances Acad Sci D. 1977 Jan;284(3):239-42.

  Abstract

  Oxygen tension (pO2) in cerebral cortex was measured by polarographic method in unanesthetized rabbits. Intravenous administration (25 mg/kg) of carbonic anhydrase inhibitors (acetazolamide, methazolamide, dichlorphenamide, sulthiame) induced an early important rise of cortical p O2, which is not dependent on increase of p O2 and p CO2 and decrease of pH in arterial blood. High dosage of acetazolamide (250 mg/kg) produced the same effect and did not suppress the increase of cortical p O2 under air-CO2 inhalation. This result suggests that CO2 might act specifically upon cerebral vessels.

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