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  • Journal
    Digital Access
    Provider
    Version
    Sage
    v. 1-, 1991-
    Acad Search Prem
    v. 7-, 1998-
    Print Access Request
    Location
    Version
    Call Number
    Items
    Stored offsite. Please request print.
    v. 6-15, 1997-2006.
    16
  • Article
    Tennekoon G, Aitchison CS, Frangia J, Price DL, Goldberg AM.
    Ann Neurol. 1979 Jun;5(6):558-64.
    The effects of chronic lead intoxication were studied by examining the optic nerve of mice given lead-containing mother's milk from day 1 to day 21 of life. Biochemical assays for myelin basic protein, 2',3'-cyclic nucleotide phosphodieterase, and cerebroside sulfotransferase showed that the total amount of myelin produced by the lead-exposed animals was decreased. Lead exposure did not alter the number of oligodendroglia or the relationship between axons and myelin sheaths. The hypomyelination was paralleled by a reduction in size of optic axons in the lead-exposed animals. The data suggest that chronic exposure to lead in developing mice results in a primary effect on neurons and that hypomyelination is secondary to reduction in axon size.
    Digital Access Access Options