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• Book

  Assessment of Pharmacodynamic Effects in Human Pharmacology

  Hippius, Hanns.

  Contents:
  pt.
  1. Psychopharmacological screening tests. pt.
  2. Non-invasive methods in cardiovascular human pharmacology.

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  pts. 1-2, 1974.

  RM301 .A83

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• Article

  Effects of beta-adrenoreceptor blocking drugs on plasma volume. Renin and aldosterone as components of their antihypertensive action.

  Gordon RD.

  Drugs. 1976;11 SUPPL 1:156-63.

  In young males with essential hypertension, propranolol and pindolol in small doses caused significant expansion of plasma volume (PV) after one month which did not prevent a reduction in BP. With higher doses, changes in PV were inconsistent and reductions in plasma renin activity (PRA) and 24-hour aldosterone excretion (AE) not closely related to BP changes. The effects of beta-adrenoreceptor blocking drugs on PV, PRA, and AE do not appear to be important components of their anti-hypertensive action.

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