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  Pharmacological Research

  Digital Access ScienceDirect v. 21-, 1989-

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  v. 21-39, 1989-99.

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• Article

  Alpha-fetoprotein and liver cell proliferation in rats fed choline-deficient diet.

  Boss JH, Rosenmann E, Zajicek G.

  Z Ernahrungswiss. 1976 Jun;15(2):211-6.

  Liver 3H-thymidine labelling index and serum AFP were determined in rats fed a standard laboratory or choline deficient diet. A significant increase in the rate of liver cell proliferation was evidenced in animals on the deficient diet. Furthermore, elevated serum AFP levels were detected in a proportion of these rats. It is suggested that increased synthesis of AFP corresponds to liver cell regeneration secondary to hepatic damage.

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