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- ArticleKolarić K, Maricić Z, Dujmović I, Mrsić Z.Strahlentherapie. 1975 Nov;150(5):521-5.The clinical picture, pathogenesis and etiology of malignant vena cava obstruction are described. The importance of using modern methods to treat this critical condition is emphasized. Furthermore, the authors examine the principles of chemotherapeutic decompression followed by irradiation. A single dose of nitrogen mustard was applied intravenously, followed by irradiation, on 24 patients with malignant vena caval obstruction. The results of this treatment are presented. The effect of this treatment was controlled by measuring the venous blood pressure and with chest X-rays. The authors conclude, that this method of decompression is successful in the palliative treatment of this syndrom.