Search
Filter Results
- Resource Type
- Article1
- Book1
- Book Print1
- Print1
- Article Type
- Research Support, U.S. Gov't, P.H.S.1
- Result From
- Lane Catalog1
- PubMed1
-
Year
- Journal Title
- J Allergy Clin Immunol1
Search Results
Sort by
- BookGeneral editor: Börje Uvnäs.Contents:
v. 1. Plenary session. Pharmacological control of release of hormones including antidiabetic drugs.--
v. 2. Effects of drugs on synthesis and mobilization of lipids.--
v. 3. New aspects of cardiac glycosides.--
v. 4. Drugs and membranes.--
v. 5. Methods for the study of pharmacological effects at cellular and subcellular levels.--
v. 6. Metabolic factors controlling duration of drug action.--
v. 7. Modern concepts in the relationship between structure and pharmacological activity.--
v. 8. Pharmacological analysis of central nervous action.--
v. 9. Bradykinin and vaso-dilating polypeptides. Pharmacology of the lung.--
v. 10 Abstracts. - ArticleOkazaki T, Okazaki A, Reisman RE, Arbesman CE.J Allergy Clin Immunol. 1975 Oct;56(4):253-61.D-glucose-6-phosphate (less than or equal to 5 x 10(-3) M), pyruvate, lactate (less than or equal to 1 X 10(-2) M), and dibutyryl cyclic AMP (less than 5 X 10(-3) M) were capable of inhibiting anapylactic histamine release in vitro from chopped guinea pig lung. In lower concentrations, pyruvic acid and lactate, as well as dibutyryl cyclic AMP, enhanced the release. Significant synergism was observed betweenpyruvate (5 X 10(-3) M) and isoproterenol (1 X 10(-8) M) in the inhibition of histamine release. The inhibitory actions of isoproterenol, glucose-6-phosphate, and pyruvate were influenced by calcium ion concentration. However, beta blockade, which diminished the isoproterenol effect, was without efect on pyruvate (1 X 10(-2) M) to the release system. Glucose-6-phosphate and isoproterenol did not have this effect. The results, together with a prevouus study, suggest that glycogenolysis may possess a role in the anaphylactic istamine release in vitro from sensitized lung fragments...