Search
Filter Results
- Resource Type
- Article1
- Journal1
- Journal Digital1
- Article Type
- Research Support, U.S. Gov't, P.H.S.1
- Result From
- Lane Catalog1
- PubMed1
-
Year
- Journal Title
- J Med Chem1
Search Results
Sort by
- JournalDigital Access ScienceDirect v. 1-13, 1979-88.Access via BOUND AND SHELVED WITH: Brain researchLocationVersionCall NumberItems
- ArticleCannon JG, O'Donnell JP, Lee T, Hoppin CR, Long JP, Ilhan M, Costall B, Naylor RJ.J Med Chem. 1975 Dec;18(12):1212-6.Secondary and tertiary amino homologs of the title compounds have been prepared, bearing an N-isopropyl group. In peripheral evaluation, certain members of the series exhibited beta-adrenergic agonist effects of lower activity than isoproterenol. N-Methyl-N-isopropyl-5,6-dihydroxytetralin exhibited marked properties consistent with its being an alpha agonist, and it is concluded that introduction of considerable bulk about the nitrogen of a catecholamine does not a priori destroy alpha-agonist effects. The compounds qualitatively paralleled the effects of dopamine in assays based upon direct intrastriatal administration in rats, although they were less potent than dopamine.