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  Drug addiction

  edited by Jasbir M. Singh, Lyle Miller, Harbans Lal.

  Contents:
  v. 1. Experimental pharmacology
  v. 2. Clinical and socio-legal aspects
  v. 3. Neurobiology and influences on behaviour
  v. 4. New aspects of analytical and clinical toxicology.

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  v. 1-4, 1972-74.

  L566 .D78

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• Article

  Evolution au cours du temps de l'émission locale du médiateur à la jonction neuromusculaire de Grenouille. [Evolution in time of transmitter release at frog neuromuscular junction].

  Vautrin J, Mambrini J.

  C R Seances Acad Sci D. 1979 Dec 10;289(15):1175-8.

  It has previously been shown that the unitary quantal end-plate potentials observed at synapses blocked by low Ca++ high Mg++ ringer, belong to distinct clusters according to their amplitude, time to peak and latency characteristics. These clusters correspond probably to distinct releasing units dispersed along the presynaptic terminal branches. The distribution versus time of the occurence of unitary potentials belonging to one latency cluster has been studied over long lasting evoked nerve activity (stimulation frequencies: 1 to 10 Hz). It was observed that transmitter release at one releasing site is statistically periodic with emitting periods separated by rest periods. At a given end-plate the period of emitting activity seems to be independent from one emitting site to another.

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  PubMed