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  • Journal
    Digital Access HathiTrust v. 7-24, 1897/98-1906/07.
    Print Access Request
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    Stored offsite. Please request print.
    v. 7-20, [21], 22-24, [25], 1897/98-1904, [1904/05], 1905-1906/07, [1907].
    20
  • Article
    Martin JL, Duvelleroy M, Teisseire B, Duruble M.
    Pflugers Arch. 1979 Oct;382(1):57-61.
    The effect of an increase in hemoglobin O2 affinity on myocardial O2 delivery was studied in a blood perfused working rat heart preparation. In a first series of experiments P50 (PO2 for which saturation is 50%) was lowered by use of carbon monoxide. The heart was alternatively perfused with the blood sample of P50 = 32 mm Hg and the blood sample of P50 = 17 mm Hg. O2 capacity of both samples was kept the same by appropriate hemodilution. In a second serie of experiments change of P50 was obtained by the use of adult human erythrocytes containing hemoglobin creteil with a P50 of 13.6 mm Hg. As P50 decreased from 25 to 10 mm Hg, coronary sinus PO2 (PcsO2) diminished from 26 +/- 2 to 18 +/- 2 mm Hg (-29 +/- 2%), coronary sinus O2 content (CcsO2) increased by 15 +/- 3%, myocardial oxygen consumption did not change significantly. The percentage of increase of coronary flow was 23 +/- 4%. Analysis of these results with a simple mathematical model of O2 delivery suggest that increase in HbO2 affinity is corrected by a simultaneous increase in coronary flow and capillary recruitment.
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